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Targeting autophagy in cardiac ischemia/reperfusion injury: A novel therapeutic strategy

Aghaei, M. and Motallebnezhad, M. and Ghorghanlu, S. and Jabbari, A. and Enayati, A. and Rajaei, M. and Pourabouk, M. and Moradi, A. and Alizadeh, A.M. and Khori, V. (2019) Targeting autophagy in cardiac ischemia/reperfusion injury: A novel therapeutic strategy. Journal of Cellular Physiology.

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Abstract

Acute myocardial infarction (AMI) is one of the leading causes of morbidity worldwide. Myocardial reperfusion is known as an effective therapeutic choice against AMI. However, reperfusion of blood flow induces ischemia/reperfusion (I/R) injury through different complex processes including ion accumulation, disruption of mitochondrial membrane potential, the formation of reactive oxygen species, and so forth. One of the processes that gets activated in response to I/R injury is autophagy. Indeed, autophagy acts as a �double-edged sword� in the pathology of myocardial I/R injury and there is a controversy about autophagy being beneficial or detrimental. On the basis of the autophagy effect and regulation on myocardial I/R injury, many studies targeted it as a therapeutic strategy. In this review, we discuss the role of autophagy in I/R injury and its targeting as a therapeutic strategy. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0
Subjects: سیستم قلب وعروق WG
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 30 Jun 2019 04:16
Last Modified: 30 Jun 2019 04:16
URI: http://eprints.goums.ac.ir/id/eprint/9965

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