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Looking beyond the standard version of the Morris water task in the assessment of mouse models of cognitive deficits

Mehla, J. and Deibel, S.H. and Faraji, J. and Saito, T. and Saido, T.C. and Mohajerani, M.H. and McDonald, R.J. (2019) Looking beyond the standard version of the Morris water task in the assessment of mouse models of cognitive deficits. Hippocampus, 29 (1). pp. 3-14.

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Abstract

Most studies investigating hippocampal-dependent learning and memory in mouse models of disease use the standard version of the Morris water task (MWT), in which a place is learned over several days. While useful in determining if there are learning and memory deficits, often it is not clear if memory acquisition, consolidation, or retrieval is affected. For rats, we developed a variant of the task in which we added a single-massed training session to a new location after the standard distributed version of the MWT. Using this version of the task, competition between these two spatial representations can then be assessed in a probe trial. We have found in rat models of Alzheimer's disease that this paradigm can detect subtle impairments that are often missed in the standard version of the MWT. To the best of our knowledge, MWT paradigm with a single-massed training session have never been used for mice. We sought to validate this paradigm for the use of assessing mouse models of disease. In the first two experiments, control mice did not have a preference for the new platform location, but instead with extensive training in the massed session displayed a preference for both the old and new locations. In the third experiment, a novel mouse model of Alzheimer's disease was impaired in the standard version of the MWT, but not in the massed training phase of this paradigm. Importantly, these data demonstrate that our paradigm is more informative in characterizing spatial learning and memory in mouse models of disease. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: water, Alzheimer disease; animal experiment; animal model; Article; cognitive defect; controlled study; female; information retrieval; learning; male; memory; Morris water maze test; mouse; mouse model; nonhuman; place preference; priority journal; rat; spatial learning
Subjects: بهداشت عمومی WA > آموزش بهداشت WA
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2019 07:02
Last Modified: 14 Apr 2019 07:02
URI: http://eprints.goums.ac.ir/id/eprint/9936

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