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Disease severity in respiratory syncytial virus infection: Role of host genetic variation

Tahamtan, A. and Askari, F.S. and Bont, L. and Salimi, V. (2019) Disease severity in respiratory syncytial virus infection: Role of host genetic variation. Reviews in Medical Virology, 29 (2).

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Abstract

Respiratory syncytial virus (RSV) infection is the most common cause of bronchiolitis and pneumonia in the pediatric population worldwide. The immunopathology of RSV infection varies considerably and severe disease occurs only in a minority of the population. There are many factors (host, viral, and environmental) that contribute to the complicated disease phenotype. In this regard, host factors are decisive for pulmonary susceptibility to RSV infection. Host genetic diversity certainly affects the balance between control of viral replication and tissue damage during RSV infection, consequently impacting on diseases outcome. In this review, we discuss the role of host genetic variation in disease caused by RSV aiming to highlight genetic risk factors for one of the most common diseases in early childhood. Our findings clearly indicate that the response of each individual to infection is influenced by genetic diversity mainly linked to the regulation of host immune responses. Future genetic association and functional studies using more powerful and consistently reproducible approaches will likely be able to confirm, refine, and expand our developing concept of RSV disease pathogenesis. © 2019 John Wiley & Sons, Ltd.

Item Type: Article
Additional Information: cited By 0
Subjects: سیستم تنفسی WF
بیماریهای واگیرWC
میکروب شناسی وایمنی شناسی QW
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
موارد کلی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 14 Apr 2019 04:23
Last Modified: 14 Apr 2019 04:23
URI: http://eprints.goums.ac.ir/id/eprint/9904

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