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Protective effect of raisin (currant) against spatial memory impairment and oxidative stress in Alzheimer disease model

Gol, M. and Ghorbanian, D. and Soltanpour, N. and Faraji, J. and Pourghasem, M. (2019) Protective effect of raisin (currant) against spatial memory impairment and oxidative stress in Alzheimer disease model. Nutritional Neuroscience, 22 (2). pp. 110-118.

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Abstract

Objectives: Alzheimer�s disease (AD) is a neurodegenerative disorder characterized by progressive pathological changes of the brain. A number of studies demonstrated compelling evidence of the importance of oxidative processes in AD pathogenesis. Raisin contains polyphenol, phenolic acid, and tannin compounds, which have antioxidant and anti-inflammatory properties. The present study was aimed to evaluate the protective effect of raisin on neurobehavioral and histological changes in rats with Alzheimer. Methods: Animal model of AD was induced by intraperitoneal injection of aluminium chloride for 60 days (100 mg/kg body weight). During these 60 days both Alzheimer�s and control rats were given 6 g of raisin per rat. At the end of the treatment, blood was collected for biochemical assessment. We used a Morris water task and passive avoidance test to assess spatial memory. Results: Our results showed that aluminium exposure significantly decreased the memory in the MWT and passive avoidance test, but in the raisin + AlCl 3 group, it significantly increased spatial memory in both tests. Also, Aluminium exposure significantly increased malondialdehyde (MDA) and decreased ferric reducing ability of plasma (ferric reducing/antioxidant power (FRAP)), while treatment with raisin significantly decreased MDA and increased FRAP in plasma of blood. Discussion: Our findings showed that raisin has a neuroprotective effect and improves the spatial memory in AD animal models. © 2017, © 2017 Informa UK Limited, trading as Taylor & Francis Group.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: aluminum chloride; malonaldehyde, adult; Alzheimer disease; animal tissue; antioxidant activity; Article; cholesterol blood level; cognitive defect; controlled study; ferric reducing antioxidant power assay; histopathology; lipid peroxidation; male; memory disorder; Morris water maze test; nerve degeneration; neuroprotection; nonhuman; oxidative stress; passive avoidance test; plasma; priority journal; rat; spatial memory
Subjects: سیستم عصبی WL
QS آناتومی انسان
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Apr 2019 08:34
Last Modified: 13 Apr 2019 08:34
URI: http://eprints.goums.ac.ir/id/eprint/9890

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