Golestan University of Medical Sciences Repository

Sex specific impact of different obesity phenotypes on the risk of incident hypertension: Tehran lipid and glucose study

Kabootari, M. and Akbarpour, S. and Azizi, F. and Hadaegh, F. (2019) Sex specific impact of different obesity phenotypes on the risk of incident hypertension: Tehran lipid and glucose study. Nutrition and Metabolism, 16 (1).

Full text not available from this repository.

Abstract

Background: To investigate the association between different obesity phenotypes and the risk of incident hypertension among both genders. Methods: The study population included 3659 Iranians (men = 1540), aged �20 years free of hypertension at baseline. Participants were classified into six categories of body mass index (BMI)-metabolic health status, in which unhealthy metabolic status was defined based on the presence of > 1 component of metabolic syndrome (MetS) using the joint interim statement (JIS) criteria or the presence of insulin resistance (IR). The association between different obesity phenotypes and incident hypertension was assessed using multivariate Cox's proportional hazard models adjusted for age, current smoking, low physical activity, diabetes mellitus, family history of premature cardiovascular disease, estimated glomerular filtration rate, phase of recruitment, BMI and systolic blood pressure, considering metabolically healthy normal weight group as the reference. Results: After a median follow-up of 11.6 years 1122 participants (men = 493) experienced hypertension. Using JIS criteria, a significant higher risk of hypertension was observed among metabolically healthy obese and well as metabolically unhealthy groups among men in the age adjusted model; however, a significant higher risk in the fully adjusted model was seen among women in the metabolically healthy obese hazard ratio (HR) 95% confidence interval (CI) 1.96(1.16-3.32) as well as metabolically unhealthy normal weight 1.98(1.37-2.86), overweight 2.08(1.49-2.90) and obese 2.06(1.27-3.30) groups. Using insulin sensitive normal weight group as the reference, among men, being overweight or obese with and without IR was significant predictors of incident hypertension in the age adjusted model; however, among women, insulin resistant overweight 1.46(1.06-2.02) and obese groups, 1.63(1.01-2.62) showed significant risk in the fully adjusted model. Conclusion: We concluded that first, there was significant difference between genders in the associations between obesity phenotypes and incident hypertension. Second, in general, metabolic status defined by MetS components as compared to IR could do better in identifying high risk women for hypertension. Third, women populations who are metabolically healthy obese using MetS definition or those with either > 1 component of metabolic syndrome or overweight/obese ones with IR should be prioritized for implementing urgent preventive strategies against hypertension focusing on lifestyle changes. © 2019 The Author(s).

Item Type: Article
Additional Information: cited By 0
Subjects: بیماریهای تغذیه ومتابولیکی WD
QU بیوشیمی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Apr 2019 07:04
Last Modified: 13 Apr 2019 07:04
URI: http://eprints.goums.ac.ir/id/eprint/9858

Actions (login required)

View Item View Item