Golestan University of Medical Sciences Repository

Induced pluripotent stem cell-derived extracellular vesicles: A novel approach for cell-free regenerative medicine

Taheri, B. and Soleimani, M. and Fekri Aval, S. and Esmaeili, E. and Bazi, Z. and Zarghami, N. (2019) Induced pluripotent stem cell-derived extracellular vesicles: A novel approach for cell-free regenerative medicine. Journal of Cellular Physiology, 234 (6). pp. 8455-8464.

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Abstract

In recent years, induced pluripotent stem cells (iPSCs) have been considered as a promising approach in the field of regenerative medicine. iPSCs can be generated from patients� somatic cells and possess the potential to differentiate, under proper conditions, into any cell type. However, the clinical application of iPS cells is restricted because of their tumorigenic potential. Recent studies have indicated that stem cells exert their therapeutic benefit via a paracrine mechanism, and extracellular vesicles have been demonstrated that play a critical role in this paracrine mechanism. Due to lower immunogenicity, easier management, and presenting no risk of tumor formation, in recent years, researchers turned attention to exosomes as potential alternatives to whole-cell therapy. Application of exosomes derived from iPSCs and their derived precursor provides a promising approach for personalized regenerative medicine. This study reviews the physiological functions of extracellular vesicles and discusses their potential therapeutic benefit in regenerative medicine. © 2018 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: article; attention; carcinogenesis; cell therapy; exosome; human; human cell; immunogenicity; induced pluripotent stem cell; physiology; precursor; regenerative medicine; scientist; whole cell
Subjects: QS آناتومی انسان
فارماکولوژی QV
> دانشکده داروسازی > فارماکولوژی QV
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Apr 2019 05:04
Last Modified: 13 Apr 2019 05:04
URI: http://eprints.goums.ac.ir/id/eprint/9840

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