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The antileukemic effects of saffron (Crocus sativus L.) and its related molecular targets: A mini review

Moradzadeh, M. and Kalani, M.R. and Avan, A. (2019) The antileukemic effects of saffron (Crocus sativus L.) and its related molecular targets: A mini review. Journal of Cellular Biochemistry, 120 (4). pp. 4732-4738.

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Abstract

Saffron (Crocus sativus L.), and its main constituents, crocin, and crocetin have shown promising effects as an antileukemic agent in animal models and cell culture systems. Saffron retards the growth of cancer cells via inhibiting nucleic acid synthesis and enhancing antioxidative system. It can induce apoptosis and chemosensitivity via inhibiting multidrug resistance proteins. Saffron also induces differentiation pathways via inhibiting promyelocytic leukemia/retinoic acid receptor-α, histone deacetylase1, and tyrosyl DNA phosphodiesterase-1 as well. The present review highlights the most recent findings on the antileukemic effects of saffron and its underlying molecular targets. The emerging evidence suggests that saffron has a selective toxicity effect against leukemic cells while is safe for the normal cells. © 2019 Wiley Periodicals, Inc.

Item Type: Article
Additional Information: cited By 0
Subjects: آسیب شناسی QZ
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Apr 2019 09:37
Last Modified: 10 Apr 2019 09:37
URI: http://eprints.goums.ac.ir/id/eprint/9812

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