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Facile and rapid in-situ synthesis of chitosan-ZnO nano-hybrids applicable in medical purposes; a novel combination of biomineralization, ultrasound, and bio-safe morphology-conducting agent

Zabihi, E. and Babaei, A. and Shahrampour, D. and Arab-Bafrani, Z. and Mirshahidi, K.S. and Majidi, H.J. (2019) Facile and rapid in-situ synthesis of chitosan-ZnO nano-hybrids applicable in medical purposes; a novel combination of biomineralization, ultrasound, and bio-safe morphology-conducting agent. International Journal of Biological Macromolecules, 131. pp. 107-116.

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Abstract

In this study, zinc oxide nanoparticle (ZnO-NPs) and also chitosan�zinc oxide (CS-ZnO-NPs) nano-hybrid were synthesized by a rapid ultrasound assisted co-precipitation method. The morphology, chemical bonding, crystal structure, UV absorption, toxicity and antibacterial properties of the CS-ZnO-NPs and ZnO-NPs were characterized. The FE-SEM (field emission scanning electron microscopy) micrographs and XRD (X-ray diffraction) analysis revealed that the used technique led to the preparation of homogeneous, ultra-thin (thickness of 20�30 nm) and highly pure ZnO sheets for the both kinds of nanoparticles. The obtained results also demonstrated a superior performance of CS-ZnO-NPs hybrid rather than ZnO-NPs in terms of antibacterial activity, cell viability and UV absorption. It was deduced that the designed biomineralization technique was a very fast and successful strategy to provide a ZnO hybrid with elevated bacterial growth inhibition and bio-safety. Furthermore, the experimental data of antibacterial analyses were compared with the curves obtained from modified Gompertz model and good accordance was observed. © 2019 Elsevier B.V.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: chitosan nanoparticle; nanohybrid; nanomaterial; unclassified drug; zinc oxide nanoparticle, antibacterial activity; Article; biomineralization; cell viability; chemical binding; crystal structure; field emission scanning electron microscopy; morphology; precipitation; synthesis; toxicity testing; ultrasound; ultraviolet spectroscopy; X ray diffraction
Subjects: QU بیوشیمی
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Apr 2019 09:03
Last Modified: 10 Apr 2019 09:03
URI: http://eprints.goums.ac.ir/id/eprint/9802

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