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Widely distribution of hematological parameters in thalassemia patients with similar α-globin genotype

Keikhaei, B. and Salehi-Fard, P. and Paridar, M. and Karimzadeh, M. and Dehghani, R. and Zamiri, A. and Takhviji, V. (2018) Widely distribution of hematological parameters in thalassemia patients with similar α-globin genotype. Frontiers in Biology.

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Abstract

Background: Thalassemia is known as the commonest monogenic disorder with an imbalanced rate of globin chains production of adult hemoglobin. Despite the available information about the thalassemia etiology, its phenotype varies from each patient to another. This study aimed to evaluate the hematological parameters of patients with the same -α3.7 homozygote and heterozygote genotypes to amend screening programs. Methods: In this observational study, we evaluated 1301 thalassemia suspected patients who referred to the Thalassemia and Hemoglobinopathy Research Center of Ahvaz University of Medical Sciences, Khuzestan, Iran during 2014–2016. According to the genotyping studies, patients divided into 2 groups with -α3.7/αα (n = 646) and -α3.7/-α3.7 (n = 181) genotypes. Thereafter, distribution of hematological parameters evaluated in both groups. Results: The mean age in heterozygous and homozygous groups was 25.7±4.5 and 26±4.4 years old, respectively. The degree of anemia was considerably varied in patients with the same genotype. MCV, RBC and MCH showed a wide distribution in patients. Conclusion: The findings presented here suggest that other molecular mechanisms along with α-globin gene mutations could be involved in determining the phenotypes of alpha thalassemia patients. © 2018, Higher Education Press and Springer-Verlag GmbH Germany, part of Springer Nature.

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: سیستم های خونی و لنفاوی WH
آسیب شناسی QZ
مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 24 Dec 2018 07:55
Last Modified: 24 Dec 2018 07:55
URI: http://eprints.goums.ac.ir/id/eprint/9778

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