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Antihypoxic activities of crataegus pentaegyn and crataegus microphylla fruits-an in vivo assay

Ebrahimzadeh, M.A. and Khalili, M. and Jafari, N. and Zareh, G. and Farzin, D. and Amin, G. (2018) Antihypoxic activities of crataegus pentaegyn and crataegus microphylla fruits-an in vivo assay. Brazilian Journal of Pharmaceutical Sciences, 54 (2).

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Abstract

The aim of this study was to evaluate anti-hypoxia activity of polyphenolic extracts of Crataegus microphylla and Crataegus pentaegyn on mice. Three experimental models of hypoxia were considered, including asphyctic hypoxia, haemic hypoxia, and circulatory hypoxia. Polyphenolic extract of both plants exhibited significant anti-hypoxic activity and prolonged animal survival time. Anti-hypoia activity of C. pentaegyn was found to be superior to that of C. microphylla in circulatory and asphyctic hypoxia. Antihypoxic activity of these extracts may be attributed to their phenolic compounds. © 2018, Faculdade de Ciencias Farmaceuticas (Biblioteca). All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: antioxidant; Crataegus microphylla extract; Crataegus pentaegyn extract; plant extract; polyphenol derivative; unclassified drug, animal experiment; animal model; antihypoxic activity; antioxidant activity; Article; controlled study; Crataegus; Crataegus microphylla; Crataegus pentaegyn; fractionation; fruit; hypoxia; in vivo study; male; nonhuman; rat; survival time
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 29 Sep 2018 07:11
Last Modified: 29 Sep 2018 07:11
URI: http://eprints.goums.ac.ir/id/eprint/9639

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