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HER-2/neu gene amplification in gastric adenocarcinoma and its relationship with clinical and pathological findings

Azarhoosh, R. and Ebneghasem, R. and Besharat, S. (2017) HER-2/neu gene amplification in gastric adenocarcinoma and its relationship with clinical and pathological findings. Journal of Gastrointestinal Oncology, 8 (6). pp. 1046-1050.

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Abstract

Background: Amplification of the HER-2/neu oncogene influences the progression of gastric cancer, its prognosis, and therapy. A precise examination of HER-2/neu-amplified tumor tissue is essential for managing disease and prescribing the appropriate treatment. This study aimed to investigate the status of HER-2/neu gene in the gastric cancer samples and its relationship with clinical and pathological information. Methods: In this study on 80 paraffin-embedded tissue samples from patients with gastric adenocarcinoma 2006-2011, DNA was extracted to quantify the gene expression levels of HER-2 using a polymerase chain reaction (PCR) method. Data were statistically analyzed by chi-square test using SPSS16.0 software. Results: PCR results indicated that HER-2/neu gene amplifications occurred in 58 of the 80 samples (72.5%). HER-2/neu gene expression was not significantly related to age and sex, but the larger tumor size and the more advanced stage were significantly associated with HER-2/neu overexpression. Conclusions: The data show the HER-2/neu gene is more amplified in stage 4 of gastric cancer with a larger size of mass. Older age and male sex also appear to be more associated with HER-2/neu gene expression. © Journal of Gastrointestinal Oncology.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: epidermal growth factor receptor 2, adult; age distribution; aged; Article; cancer staging; case control study; controlled study; female; gene amplification; gene expression; gene sequence; genetic association; HER 2 gene; human; human tissue; major clinical study; male; sex difference; stomach adenocarcinoma; tumor volume
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 27 Dec 2017 08:02
Last Modified: 27 Dec 2017 08:02
URI: http://eprints.goums.ac.ir/id/eprint/9497

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