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Antiretroviral drug resistance mutations among HIV treatment failure patients in Tehran, Iran

Farrokhi, M. and Moallemi, S. and Shirkoohi, R. and Golmohammadi, R. and Ahsani-Nasab, S. and Sardashti, S. and Abbasian, L. and Baesi, K. and Mohraz, M. (2017) Antiretroviral drug resistance mutations among HIV treatment failure patients in Tehran, Iran. Iranian Journal of Public Health, 46 (9). pp. 1256-1264.

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Abstract

Background: This study aimed to determine drug resistance mutations in patients with virological failure and find correlation between HIV drug resistance test and viral load. Methods: Blood sample was collected from 51 patients who suspicious treatment failure in the center of Imam Khomeini Hospital, Tehran, Iran in 2015. Viral voluntary counseling and testing load test was done and the patients with viral load above 1000 copies choose for detection of drug resistance mutations by genotyping method (29 patients). Results: The majority of patients (82.75) harbored the HIV subtype CRF 35 A-D. The 86.2 patients compromised at least one resistance mutation. The analysis of reverse transcriptase showed M184V (68.9), T215YISF (44.8), K103N (27.6) and the analysis results of protease revealed G73SC (13.8) and I47VA (6.9). Eventually, the significant correlation between viral load and drug resistance was found. Conclusion: The result of our research stress the significance of recognizing drug resistant on time that prohibits the accumulation of drug resistance mutation and circulates the resistance strain of HIV-1 virus and the importance of national study according to the reliable findings for treatment guidelines. © 2017, Iranian Journal of Public Health. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 09 Oct 2017 05:03
Last Modified: 09 Oct 2017 05:03
URI: http://eprints.goums.ac.ir/id/eprint/9468

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