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Propranolol decreases the post-operative pain and analgesic administration following abdominal hysterectomy

Teimoori, B. and Khoshfetrat, M. and Beyrami, F. and Sakhavar, N. and Dehbashi, Z. and Narouie, B. and Davarian, A. (2012) Propranolol decreases the post-operative pain and analgesic administration following abdominal hysterectomy. Life Science Journal, 9 (3). pp. 1216-1220.

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Abstract

Post-operative pain results in many complications. Studies suggest beta blockers to be effective in decreasing postoperative pain and analgesic requirements. This study evaluated the influence of perioperative administration of 40mg orally propranolol on patients' post-operative pain score and analgesic consumption following abdominal hysterectomy. In this double-blind randomized clinical trial, 73 women who had referred for elective abdominal hysterectomy surgery during years 2010-2011 were reviewed. Patients were randomly divided into case (receiving 40 mg orally propranolol tablet 30 min before surgery) and control (receiving orally placebo 30 min before surgery). General anesthesia was done the same for both groups. Postoperative time of first need to morphine, total morphine consumption dose and pain severity during the first 24 hours after surgery was measured among both groups. age and hysterectomy indication was not statistically different between two groups (p>0.05). Total morphine consumption in the propranolol group (2.85±2.5 mg) was lower than control group (10.35±2.2 mg) (p<0.001). The Initial morphine administration time (min) in the propranolol group was significantly longer than the control group (998.7 ± 49 vs. 261.7 ± 139.1) (p<0.001). The Pain Score (VAS scoring) (Mean±SD) in propranolol group was lower than the control group (1.03±0.58 vs. 2.76 ±0.8) (p< 0.001). administration of 40mg orally propranolol 30 minutes before abdominal hysterectomy is effective in decreasing patients' post-operative pain and morphine administration dosage. It also elongates the Initial morphine administration time in the first 24 hours following abdominal hysterectomy.

Item Type: Article
Additional Information: cited By 1
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Aug 2017 06:13
Last Modified: 13 Aug 2017 06:13
URI: http://eprints.goums.ac.ir/id/eprint/9393

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