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Sequence analysis of cox1 and nad1 genes in Echinococcus granulosus G3 genotype in camels (Camelus dromedarius) from central Iran

Sharbatkhori, M. and Fasihi Harandi, M. and Mirhendi, H. and Hajialilo, E. and Kia, E.B. (2011) Sequence analysis of cox1 and nad1 genes in Echinococcus granulosus G3 genotype in camels (Camelus dromedarius) from central Iran. Parasitology Research, 108 (3). pp. 521-527.

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Abstract

Nineteen hydatid cyst isolates collected from camels in central Iran were subjected to sequences analysis of mitochondrial cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) genes. A consensus sequence obtained containing 366 nucleotides for cox1 and 471 nucleotides for nad1 genes. Overall, the camel isolates indicated five different sequences in cox1 and nine in nad1 genes. The sequences analysis indicated that 26.3, 42.1, and 31.6 of isolates belonging to G1, G3, and G6 genotypes of Echinococcus granulosus, respectively. The isolates with G3 genotype indicated one cox1 sequence having 100 homology with reference G3 sequence (AN: M84663) and two different nad1 sequences, one having100 homology with reference G3 sequence (AN: AJ237634) and the other with a silent mutation (G to A) in position 279. The presence of G3 genotype (buffalo strain) of E. granulosus as dominant genotype in camels is emphasized. As G3 genotype has formerly been reported in human, the epidemiological role of camels is warranted in future surveys. © Springer-Verlag 2010.

Item Type: Article
Additional Information: cited By 40
Uncontrolled Keywords: cytochrome c oxidase; cytochrome c oxidase subunit 1; reduced nicotinamide adenine dinucleotide dehydrogenase; reduced nicotinamide adenine dinucleotide dehydrogenase subunit 1; unclassified drug, article; camel; Camelus dromedarius; controlled study; Echinococcus granulosus; gene amplification; gene mutation; gene sequence; genetic variability; genotype; Iran; liver hydatid cyst; lung hydatid cyst; nonhuman; nucleotide sequence; phylogeny; population structure; priority journal; sequence analysis; sequence homology, Animals; Base Sequence; Camels; Consensus Sequence; DNA, Mitochondrial; DNA, Protozoan; Echinococcosis; Echinococcus granulosus; Electron Transport Complex IV; Genotype; Iran; Molecular Sequence Data; Mutation; NADH Dehydrogenase; Polymerase Chain Reaction; Sequence Analysis, DNA, Camelidae; Camelus dromedarius; Echinococcus granulosus
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Aug 2017 05:43
Last Modified: 13 Aug 2017 05:43
URI: http://eprints.goums.ac.ir/id/eprint/9385

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