Golestan University of Medical Sciences Repository

Prevalence of hepatitis D virus infection in hepatitis B surface antigen-positive subjects in Golestan province, northeast Iran

Roshandel, G. and Semnani, S. and Abdolahi, N. and Besharat, S. and Keshtkar, A.-A. and Joshaqani, H. and Moradi, A. and Kalavi, K. and Jabbari, A. and Kabir, M.J. and Hosseini, S.A. and Sedaqat, S.M. and Danesh, A. and Roshandel, D. and Hedayat-Mofidi, S.M. (2008) Prevalence of hepatitis D virus infection in hepatitis B surface antigen-positive subjects in Golestan province, northeast Iran. Journal of Microbiology, Immunology and Infection, 41 (3). pp. 227-230.

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Background and Purpose: Hepatitis D virus (HDV) is a defective RNA virus dependent on hepatitis B virus (HBV) infection for its replication and expression. It is known that coexistent infection with HDV tends to aggravate the course of HBV-associated liver disease. This study was carried out to determine the seroprevalence of HDV among hepatitis B surface antigen (HBsAg)-positive individuals in the northeast part of Iran. Methods: 139 HBsAg-positive subjects detected from a population-based single stage cluster sampling in Golestan province of Iran were enrolled. All cases were evaluated for the presence of anti-HDV antibodies using commercially available enzyme-linked immunoabsorbent assay kits. Logistic regression was used to determine the relationship between independent variables and HDV seropositivity. Results: Of 139 cases, 68 were males (48.9) and 71 were females (51.1). The mean age was 41.9 ± 11.3 years (range, 25-64 years). Anti-HDV antibody was positive in 8 subjects (5.8), with a female predominance (9.9 vs 1.5, p=0.06; odds ratio, 7.32; 95 confidence interval, 0.87-61.23). No significant relationship was seen between anti-HDV seropositivity and demographic factors such as age, place of residence and marital status. Conclusions: These findings show that HDV infection is endemic in Golestan province (northeast) of Iran. Seroprevalence of anti-HDV in the present study was higher than in some previous studies from other parts of Iran. Our results suggest that the prevalence of HBV/HDV coinfection in Golestan province of Iran has increased during the last decade. Therefore, practitioners and health care managers should be made aware of the risk of dual infection with HBV and HDV. © 2008 Journal of Microbiology, Immunology and Infection.

Item Type: Article
Additional Information: cited By 19
Uncontrolled Keywords: hepatitis B surface antigen; hepatitis antibody; hepatitis B surface antigen, adult; antibody detection; article; cluster analysis; comorbidity; confidence interval; delta agent hepatitis; demography; endemic disease; enzyme linked immunosorbent assay; female; hepatitis B; Hepatitis B virus; human; Iran; logistic regression analysis; major clinical study; male; mixed infection; seroepidemiology; seroprevalence; blood; epidemiology; hepatitis B; Iran; middle aged; risk factor; statistical model, Adult; Endemic Diseases; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis Antibodies; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis D; Humans; Iran; Logistic Models; Male; Middle Aged; Risk Factors; Seroepidemiologic Studies
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری > مدیریت تحقیقات وفناوری واطلاع رسانی
Depositing User: GOUMS
Date Deposited: 13 Aug 2017 05:38
Last Modified: 13 Aug 2017 05:38
URI: http://eprints.goums.ac.ir/id/eprint/9383

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