Golestan University of Medical Sciences Repository

Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran

Roshandel, G. and Merat, S. and Sotoudeh, M. and Khoshnia, M. and Poustchi, H. and Lao-Sirieix, P. and Malhotra, S. and O'Donovan, M. and Etemadi, A. and Nickmanesh, A. and Pourshams, A. and Norouzi, A. and Debiram, I. and Semnani, S. and Abnet, C.C. and Dawsey, S.M. and Fitzgerald, R.C. and Malekzadeh, R. (2014) Pilot study of cytological testing for oesophageal squamous cell dysplasia in a high-risk area in Northern Iran. British Journal of Cancer, 111 (12). pp. 2235-2241.

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Background:Oesophageal squamous cell carcinoma (ESCC) is a fatal disease with 5-year survival rates of <5 in Northern Iran. Oesophageal squamous dysplasia (ESD) is the precursor histologic lesion of ESCC. This pilot study was conducted to assess the feasibility, safety, and acceptability of non-endoscopic cytological examination of the oesophagus and to provide initial data on the accuracy of cytological atypia for identifying patients with ESD in this very-high-risk area.Methods:Randomly selected asymptomatic participants of the Golestan Cohort Study were recruited. A cytological specimen was taken using a capsule sponge device and evaluated for atypical cells. Sections of the cytological specimen were also stained for p53 protein. Patient acceptability was assessed using a visual analogue scale. The cytological diagnosis was compared with a chromoendoscopic examination using Lugol's solution.Results:Three hundred and forty-four subjects (43 male, mean (s.d.) age 55.6 (7.9) years) were referred to the study clinic. Three hundred and twelve met eligibility criteria and consented, of which 301 subjects (96.5) completed both cytological and endoscopic examinations. There were no complications. Most of the participants (279; 92.7) were satisfied with the examination. The sensitivity and specificity of the cytological examination for identifying subjects with high-grade ESD were 100 and 97, respectively. We found an accuracy of 100 (95 CI=99-100) for a combination of cytological examination and p53 staining to detect high-grade ESD.Conclusions:The capsule sponge methodology seems to be a feasible, safe, and acceptable method for diagnosing precancerous lesions of the oesophagus in this population, with promising initial accuracy data for the detection of high-grade ESD. © 2014 Cancer Research UK.

Item Type: Article
Additional Information: cited By 5
Uncontrolled Keywords: protein p53, adult; Article; controlled study; cytodiagnosis; diagnostic accuracy; diagnostic test accuracy study; esophageal squamous cell carcinoma; female; gold standard; high risk population; human; human cell; Iran; major clinical study; male; middle aged; patient safety; pilot study; precancer; predictive value; priority journal; program acceptability; program feasibility; randomized controlled trial; sensitivity and specificity; visual analog scale; carcinoma in situ; Carcinoma, Squamous Cell; cohort analysis; Esophageal Neoplasms; pathology; Precancerous Conditions; risk factor, Carcinoma in Situ; Carcinoma, Squamous Cell; Cohort Studies; Esophageal Neoplasms; Female; Humans; Iran; Male; Middle Aged; Pilot Projects; Precancerous Conditions; Risk Factors
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Aug 2017 05:35
Last Modified: 13 Aug 2017 05:35
URI: http://eprints.goums.ac.ir/id/eprint/9382

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