Golestan University of Medical Sciences Repository

Response to the hepatitis B virus vaccine in Iranian infants

Moradi, A. and Khodabakhshi, B. and Roshandel, G. and Kalavi, K. and Besharat, S. and Semnani, S. (2009) Response to the hepatitis B virus vaccine in Iranian infants. Hepatitis Monthly, 9 (3). pp. 229-231.

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Background and Aims: The aim of this study was to evaluate infants' immune response to the hepatitis B virus (HBV) vaccination. Methods: This was a cross-sectional descriptive study carried out on 215 infants 7-12 months of age in the Golestan province in northeastern Iran in 2006. These children had already received the complete three-dose vaccination against hepatitis B. The serumal levels of hepatitis B surface antigen antibody (anti-HBs), hepatitis B core antibody (anti-HBc), and hepatitis B surface antigen (HBsAg) were determined using enzyme-linked immunosorbent assay (ELISA). Results: Of all 215 participants, 55.3 were males. All of them were 7-12 months old. Eighty-six percent of the studied cases responded positively to the vaccination. The response rate for males was lower than the rate for females (P = 0.34). Conclusions: We found that non-response to HBV vaccination is an important issue in our area. Further studies are needed to assess the influence of major factors such as the vaccination procedure, the type and site of inoculation, and vaccine preservation and transportation.

Item Type: Article
Additional Information: cited By 6
Uncontrolled Keywords: hepatitis B core antibody; hepatitis B surface antibody; hepatitis B surface antigen; hepatitis B vaccine, age distribution; antibody blood level; article; child; child care; controlled study; cross-sectional study; drug response; enzyme linked immunosorbent assay; female; hepatitis B; human; immune response; immunization; infant; Iran; major clinical study; male; sex difference
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Aug 2017 04:49
Last Modified: 13 Aug 2017 04:49
URI: http://eprints.goums.ac.ir/id/eprint/9372

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