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Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPARγ-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population

Meshkani, R. and Taghikhani, M. and Larijani, B. and Bahrami, Y. and Khatami, S. and Khoshbin, E. and Ghaemi, A. and Sadeghi, S. and Mirkhani, F. and Molapour, A. and Adeli, K. (2007) Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPARγ-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population. Clinical Chemistry and Laboratory Medicine, 45 (4). pp. 477-482.

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Abstract

Background: The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPARγ-2) gene has been variably associated with insulin resistance, obesity and type 2 diabetes in several populations. However, this association has not been studied in Iranian subjects and we hypothesized that this variation might be associated with insulin resistance, type 2 diabetes and related metabolic traits in this population. Methods: The Pro12Ala genotypes were determined by PCR-restriction fragment length polymorphism in 696 unrelated subjects including 412 non-diabetic controls and 284 type 2 diabetic patients. Results: The frequency of the Ala allele was 9.4 and 5.9 in controls and type 2 diabetic subjects, respectively adjusted odds ratio (OR) 0.457, p=0.005. The Ala allele did not show a significant effect on anthropometric and biochemical parameters in the type 2 diabetic group, whereas in non-diabetic subjects, carriers of the Ala allele had significantly lower fasting insulin (p=0.007) and homeostasis model assessment of insulin resistance (HOMA-IR) (p=0.009) levels compared to Pro/Pro subjects. Multivariate logistic regression analysis showed that Pro12Ala polymorphism was an independent determinant of type 2 diabetes in this population. Conclusions: Our results for a sample of Iranian type 2 diabetes cases and controls provide evidence that the Pro/Ala genotype of the PPARγ-2 gene is associated with insulin sensitivity and may also have protective role against type 2 diabetes. ©2007 by Walter de Gruyter.

Item Type: Article
Additional Information: cited By 18
Uncontrolled Keywords: alanine; insulin; peroxisome proliferator activated receptor gamma 2; proline, adult; article; controlled study; disease association; female; gene frequency; genetic association; genetic polymorphism; genotype; human; insulin resistance; insulin sensitivity; Iran; major clinical study; male; non insulin dependent diabetes mellitus; polymerase chain reaction; prevalence; priority journal; restriction fragment length polymorphism, Alanine; Base Sequence; Diabetes Mellitus, Type 2; DNA Primers; Genetic Predisposition to Disease; Humans; Insulin Resistance; Iran; Polymorphism, Genetic; PPAR gamma; Proline
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Aug 2017 04:34
Last Modified: 13 Aug 2017 04:34
URI: http://eprints.goums.ac.ir/id/eprint/9368

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