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Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts

Khori, V. and Nayebpour, M. and Semnani, S. and Golalipour, M.J. and Marjani, A. (2008) Prolongation of AV nodal refractoriness by Ruta graveolens in isolated rat hearts. Saudi Medical Journal, 29 (3). pp. 357-363.

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Objectives: To evaluate concentration-dependent effects of total extract of Rusta graveolens and its purified alkaloid fraction on the nodal basic and functional properties. Methods: In the present experimental study, we used the Langendorff model for perfusion of isolated rat hearts to determine the effects of various concentrations of methanolic extract of Rue (1.25 × 10-6 weight per volume percent W/V; 2.5 × 10-6% W/V; 3.7 × 10-6 % W/ V) and total alkaloid of Rue (0.25 × 10-6% W/V; 0.5 × 10-6% W/V) on electrophysiological properties of cardiac tissue. Selective stimulation protocols were used to independently quantify atrioventricular (AV) nodal recovery, facilitation, and fatigue. We used 3 groups (N=24) of isolated perfused rat AV nodal preparations to assess the effect of Rue extracts. The study was carried out in October 2006 in the electrophysiology laboratory of the Cardiovascular Research Center of Golestan University of Medical Sciences, Golestan, Gorgan, Iran. Results: Our results showed that both the total plant extract and the alkaloid fraction of Ruta graveolens had a similar trend of action on nodal conduction time and refractorines. Furthermore, we observed increased atrioventricular conduction time (83±4 to 108±5 msec) and functional refractory period (157.6±3 to 163.7±4 msec) at a maximum concentration of 3.75 × 10-6% W/V. Conclusion: The above results indicated a potential antiarrhythmic effect of Ruta graveolens in treating supra ventricular tachyarrhythmia.

Item Type: Article
Additional Information: cited By 4
Uncontrolled Keywords: alkaloid derivative; flavonoid; methanol; plant glycoside; Ruta graveolens extract; saponin derivative; tannin derivative; verapamil; antiarrhythmic agent; plant extract, animal experiment; animal tissue; antiarrhythmic activity; article; concentration response; controlled study; drug effect; drug isolation; drug mechanism; heart atrioventricular node; heart electrophysiology; heart muscle conduction system; heart perfusion; heart stimulation; Iran; isolated heart; male; nonhuman; rat; supraventricular tachycardia; tissue section; animal; electrophysiology; Rutaceae; Sprague Dawley rat; time, Animals; Anti-Arrhythmia Agents; Atrioventricular Node; Electrophysiology; Male; Plant Extracts; Rats; Rats, Sprague-Dawley; Ruta; Time Factors
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Aug 2017 04:14
Last Modified: 13 Aug 2017 04:15
URI: http://eprints.goums.ac.ir/id/eprint/9366

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