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Proliferation of the β -cells of pancreas in diabetic Rats treated with Urtica dioica [Proliferación de las células β del páncreas en ratas diabéticas tratadas con Urtica dioica]

Golalipour, M.J. and Ghafari, S. and Kouri, V. and Kestkar, A.A. (2010) Proliferation of the β -cells of pancreas in diabetic Rats treated with Urtica dioica [Proliferación de las células β del páncreas en ratas diabéticas tratadas con Urtica dioica]. International Journal of Morphology, 28 (2). pp. 399-404.

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Abstract

This investigation was carried out to evaluate the effect of the extract of Urtica dioica leaves on hyperglycemia and quantitative changes of β -cells in streptozotocin-diabetic rats. Forty male Wistar rats were allocated in groups of normal, diabetic, treatment and protective. Hyperglycemia induced by administrating one dose of 80 mg/kg streptozotocin (STZ) intraperitoneally. Animals in treatment group received Urtica dioica (100 mg/kg/day) for 4 weeks intraperitoneally, one week after injection of STZ. In protective group animals received U. dioica (100 mg/kg/day) for 5 days before inducing diabetes. After five weeks the animals were sacrificed and whole pancreas removed. Pancreas specimens were used for quantitative morphometric analysis after Chromealum hematoxiline - phloxine staining. The mean ± SE of β -cells in non hyperglycemic animals in protective group was higher than in hyperglycemic animals in the same group (54.33 ± 2.4 versus 1.25 ± 0.5, P<0.05). Hyperglycemia was improved in 6 (60) of rats in protective group and 1 (10) rat in treatment group OR=0.07 (CI 95: 0.0-1.1, p=0.06). The logistic regression analysis showed an association between decrease of blood glucose, increase of number of b-cells and administration of Urtica before induction of diabetes. This study showed proliferation of b-cells when of the U. dioica leaves extract (100 mg/kg/day) administrated before induction of diabetes in animal model.

Item Type: Article
Additional Information: cited By 8
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 13 Aug 2017 03:28
Last Modified: 13 Aug 2017 03:29
URI: http://eprints.goums.ac.ir/id/eprint/9358

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