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Gamma radiation-induced impairment of hippocampal neurogenesis, comparison of single and fractionated dose regimens Deterioro de la neurogénesis en el hipocampo inducida por radiación gamma, comparación de los regímenes de dosis única y fraccionada

Khoshbin khoshnazar, A.R. and Jahanshahi, M. and Azami, N.S. (2012) Gamma radiation-induced impairment of hippocampal neurogenesis, comparison of single and fractionated dose regimens Deterioro de la neurogénesis en el hipocampo inducida por radiación gamma, comparación de los regímenes de dosis única y fraccionada. International Journal of Morphology, 30 (1). pp. 145-149.

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Abstract

Radiation therapy of the brain is associated with many consequences, including cognitive disorders. Pathogenesis of radiation induced cognitive disorder is not clear, but reduction of neurogenesis in hippocampus may be an underlying reason. 24 adult male rats entered to study. Radiation absorbed dose to midbrain was 10 Gy, delivered by routine cobalt radiotherapy machine which its output was measured 115.24 cGy/min. The rats were divided in four groups of sixes, including groups of control, single fraction 10 Gy, fractionated 10 Gy and finally anaesthesia sham group. Number of pyramidal nerve cells was counted in two regions of hippocampus formation (CA1 and CA3). The radiation could reduce the number of cells in two regions of hippocampus significantly (p=0.000). It seems fractionated 10 Gy irradiation to more efficient than single fraction, while role of anaesthesia drug should be cautiously assessed. Moreover the rate of neurogenesis reduction was determined the same in these regions of hippocampus meaning the same radiosensitivity of cells.

Item Type: Article
Additional Information: cited By 0
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 25 Jul 2017 07:30
Last Modified: 25 Jul 2017 07:30
URI: http://eprints.goums.ac.ir/id/eprint/9328

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