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Eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease

Foroutan, M. and Norouzi, A. and Molaei, M. and Mirbagheri, S.A. and Irvani, S. and Sadeghi, A. and Derakhshan, F. and Tavassoli, S. and Besharat, S. and Zali, M. (2010) Eosinophilic esophagitis in patients with refractory gastroesophageal reflux disease. Digestive Diseases and Sciences, 55 (1). pp. 28-31.

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Background Eosinophilic esophagitis is among the causes of refractory reflux disease. Biopsy of esophagus is the gold standard for diagnosis. In this study we determined the frequency of eosinophilic esophagitis (EE) in refractory reflux cases referred to Motility Department of Shahid Beheshti Research Center of Gastroenterology and Liver Disease, Tehran, Iran. Methods In this cross-sectional study, 68 cases with refractory reflux disease underwent endoscopy and had biopsies taken. Specimens were stained by hematoxylin and eosin and two independent pathologists confirmed the diagnosis of eosinophilic esophagitis. Results Mean (standard deviation, SD) age at diagnosis was 41.8 (10.94) years. All had allergy or atopy, and unknown dysphagia was noted for 66. Endoscopic findings were as follows: esophagitis (33.3), rings (33.3), and whitish plaques (33.3). Prevalence of eosinophilic esophagitis was 8.8 (N = 6; one man and five women). No statistical difference in demographic variables was found between eosinophilic esophagitis cases and others, except for history of atopy, food impaction, and endoscopic features (P value <0.005). Conclusion Eosinophilic esophagitis should be considered in the differential diagnosis of any cases with refractory reflux who complain of chronic unexplained dysphagia, with history of recurrent food impaction, and atopy or abnormal endoscopic features. © 2009 Springer Science+Business Media, LLC.

Item Type: Article
Additional Information: cited By 38
Uncontrolled Keywords: eosin; hematoxylin; omeprazole, adult; allergy; article; atopy; controlled study; cross-sectional study; demography; dysphagia; endoscopy; eosinophilic esophagitis; esophagitis; female; gastroesophageal reflux; groups by age; human; major clinical study; male; pathologist; prevalence; priority journal; eosinophilia; esophagitis; esophagoscopy; esophagus; gastroesophageal reflux; immediate type hypersensitivity; pathology, Adult; Eosinophilia; Esophagitis; Esophagoscopy; Esophagus; Female; Gastroesophageal Reflux; Humans; Hypersensitivity, Immediate; Male
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 25 Jul 2017 07:12
Last Modified: 25 Jul 2017 07:12
URI: http://eprints.goums.ac.ir/id/eprint/9321

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