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Complete improvement in a patient with multiple irreversible defects of the left ventricle on 99m technetium-sestamibi SPECT after percutaneous coronary intervention.

Javadi, H. and Porpiranfar, M.A. and Semnani, S. and Jallalat, S. and Yavari, P. and Mogharrabi, M. and Hooman, A. and Amini, A. and Barekat, M. and Iranpour, D. and Assadi, M. and Asli, I.N. (2012) Complete improvement in a patient with multiple irreversible defects of the left ventricle on 99m technetium-sestamibi SPECT after percutaneous coronary intervention. European review for medical and pharmacological sciences, 16 Sup. pp. 113-116.

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Abstract

99mTc-sestamibi has been investigated as a potential viability marker; initial studies have shown good concordance between 201Tl and 99mTc-sestamibi activities in both viable and nonviable myocardium. However, assessment of myocardial viability by 99mTc-sestamibi remains controversial for tissue recovery after revascularization. Here, we present a patient with several regions of severely diminished and irreversible (defect persisting in both early and delay images of each set scanning) defects on initial scan which were dissolved completely on the follow up scan after an intervention. In a 75 year-old Asian woman with acute myocardial infarction who received thrombolytic therapy and subjected to percutaneous coronary angiography (PCI) on day 28 after acute myocardial infarction(MI), resting 99mTc-sestamibi SPECT was applied on day 4 (initial scan) and 138 (follow up scan) after acute MI at 30 and 180 min after injection of tracer (740 MBq); Two-dimensional echocardiography was carried out at the same time. On the initial image set, there was irreversible defects in the apex, anteroapical, inferoapical, anteroseptal, septal and also anterior walls, while the follow up image was normal in all regions.The angiography intervention showed just significant stenosis on left anterior descending (LAD) vessel (95). This may highlight the failure of 99mTc-sestamibi as a marker of myocardial viability and also mandate further validating of the procedure with follow up scan or other modalities for myocardial viability investigation.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: diagnostic agent; methoxy isobutyl isonitrile technetium tc 99m, aged; article; case report; echocardiography; female; heart left ventricle function; heart ventricle; human; scintiscanning; single photon emission computer tomography; transluminal coronary angioplasty, Aged; Angioplasty, Balloon, Coronary; Echocardiography; Female; Heart Ventricles; Humans; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; Ventricular Function, Left
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 25 Jul 2017 03:55
Last Modified: 25 Jul 2017 03:56
URI: http://eprints.goums.ac.ir/id/eprint/9307

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