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Chromosome aberrations after high-dose 131I and 99mTc-MIBI administration using a micronucleus assay

Asli, I.N. and Mosaffa, N. and Mogharrabi, M. and Hooman, A. and Tabei, F. and Javadi, H. and Shafei, B. and Seyedabadi, M. and Assadi, M. (2010) Chromosome aberrations after high-dose 131I and 99mTc-MIBI administration using a micronucleus assay. Nuclear Medicine Communications, 31 (4). pp. 307-310.

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Abstract

Objective: We evaluated the potential detrimental cytogenetic effects of 99mTc-methoxyisobutyl isonitrile (MIBI) and 131I on patients who were exposed to the radiopharmaceutics for cardiac imaging or thyroid cancer therapy, respectively. Methods: Mononuclear leukocytes were isolated both before and after radiopharmaceutical administration and subsequently cultured. Micronuclei frequency was then assessed and microscopic evaluation of apoptosis was conducted. Results: Small statistically insignificant augmentation in the percentage of micronuclei from 10.9 ± 3.8 to 11.3±2.4 was observed in the 99mTc-MIBI group. In contrast, 131I elicited a notable augmentation of micronuclei from 6.3± 2.2 to 9.6± 3.1 at 3.7GBq, and 6 ±1.5 to 9.2±2.7 at 5.55GBq (P <0.05). Conclusion: Our results showed that there were no remarkable alterations either in the micronuclei incidence or in the percentage of apoptotic lymphocytes after in-vivo exposure to radiopharmaceutical imaging, which provides evidence to reduce the growing concern about the safety issue of cardiac imaging with 99mTc-MIBI, whereas the deleterious effects of 131I must be considered when it is applied to thyroid cancer treatment. © 2010 Wolters Kluwer Health | Lippincott Williams & Wilkins.

Item Type: Article
Additional Information: cited By 2
Uncontrolled Keywords: iodine 131; methoxy isobutyl isonitrile technetium tc 99m; diagnostic agent; methoxy isobutyl isonitrile technetium tc 99m; radioactive iodine, adult; apoptosis; article; cancer therapy; cardiac imaging; chromosome aberration; clinical article; cytogenetics; drug exposure; drug megadose; drug safety; female; human; human cell; leukocyte culture; male; micronucleus test; mononuclear cell; thyroid cancer; cell differentiation; chromosome aberration; genetics; methodology; middle aged; myocardial perfusion imaging; pathology; radiation dose; radiation exposure; thyroid tumor, Adult; Cell Differentiation; Chromosome Aberrations; Female; Humans; Iodine Radioisotopes; Male; Micronucleus Tests; Middle Aged; Myocardial Perfusion Imaging; Radiation Dosage; Technetium Tc 99m Sestamibi; Thyroid Neoplasms
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 22 Jul 2017 09:00
Last Modified: 22 Jul 2017 09:00
URI: http://eprints.goums.ac.ir/id/eprint/9301

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