Golestan University of Medical Sciences Repository

CCR5-Delta32 allele is associated with the risk of developing multiple sclerosis in the Iranian population

Shahbazi, M. and Ebadi, H. and Fathi, D. and Roshandel, D. and Mahamadhoseeni, M. and Rashidbaghan, A. and Mahammadi, N. and Mahammadi, M.R. and Zamani, M. (2009) CCR5-Delta32 allele is associated with the risk of developing multiple sclerosis in the Iranian population. Cellular and Molecular Neurobiology, 29 (8). pp. 1205-1209.

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Abstract

The 32-base pair deletion on the C-C chemokine receptor 5 gene (CCR5-delta32) is known as a protective allele against immune system disorders. We have studied this variation in Iranian multiple sclerosis (MS) patients and healthy controls. DNA samples were prepared from the whole blood of 254 patients with MS and 380 healthy controls. We amplified the fragment including the CCR5-delta32 polymorphism and visualized the products in a documentation system after agarose gel electrophoresis. Data were analysed using one-way ANOVA and Fisher's exact tests with SPSS-v13 and STATA-v8 software. The delta32 allele was more frequent in MS patients when compared with controls (OR = 2.3, P < 0.0001). Also, we found a significant difference in the frequency of the delta32/delta32 genotype among patients and controls (OR = 7.4, P < 0.001). The mean age at onset and progression index was not significantly different between patients with various genotypes. According to our study, the delta32 allele of the CCR5 gene might be a predisposing factor for MS development in the Iranian population. However, there were no associations between this polymorphism and the clinical course of the disease in this study. © 2009 Springer Science+Business Media, LLC.

Item Type: Article
Additional Information: cited By 14
Uncontrolled Keywords: chemokine receptor CCR5; DNA, adult; agar gel electrophoresis; allele; article; blood sampling; chemokine receptor CCR5 delta32; controlled study; disease predisposition; female; gene deletion; genetic polymorphism; genetic variability; genotype; human; immune system; Iran; major clinical study; male; multiple sclerosis; onset age; population research; priority journal
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 22 Jul 2017 08:46
Last Modified: 22 Jul 2017 08:46
URI: http://eprints.goums.ac.ir/id/eprint/9298

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