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Brain single photon emission computed tomography with Tc-99m MIBI or Tc-99m ECD in comparison to MRI in multiple sclerosis

Assadi, M. and Salimipour, H. and Seyedabadi, M. and Saberifard, J. and Javadi, H. and Nabipour, I. and Nemati, R. (2010) Brain single photon emission computed tomography with Tc-99m MIBI or Tc-99m ECD in comparison to MRI in multiple sclerosis. Clinical Nuclear Medicine, 35 (9). pp. 682-686.

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Abstract

Purpose: To evaluate whether or not brain single photon emission computed tomography (SPECT) with Tc-99m MIBI or Tc-99m ECD (ethyl cysteinate dimer) can detect any abnormality in patients with definite multiple sclerosis (MS). We then compared these values with the results of T1, T2, and fluid-attenuated inversion recovery in magnetic resonance imaging (MRI). Materials and Methods: A total of 16 patients with proved MS were enrolled in the study, and the MRI with and without gadolinium contrast and also brain SPECT with Tc-99m MIBI (8 cases) or Tc-99m ECD (8 other cases) were performed. Results: MRI studies was performed in 16 patients (13 women and 3 men, aged 16-38 years) and an average of 10.47, 3.7, 5.3, 1.7, and 0.9 lesions was found in respect in periventricular white matter, juxtacortical white matter, corpus callosum, cerebellar peduncles, and brainstem, whereas brain SPECT with Tc-99m MIBI or Tc-99m ECD detected no abnormality. In addition, 6 cases had some degree of contrast enhancement. Conclusions: It seems that brain SPECT with Tc-99m MIBI or Tc-99m ECD would not improve this insufficiency. The small sizes of some plaques, particularly in chronic atrophic form of lesions, and the possibility of deeper anatomic positions of plaques can explain to some extent why the MS lesions were impossible to delineate on brain scan, although additional studies are needed. Copyright © 2010 by Lippincott Williams & Wilkins.

Item Type: Article
Additional Information: cited By 5
Uncontrolled Keywords: cysteine ethyl ester tc 99m; methoxy isobutyl isonitrile technetium tc 99m, adolescent; adult; article; brain scintiscanning; brain stem; cerebellar peduncle; clinical article; contrast enhancement; corpus callosum; female; human; male; multiple sclerosis; nuclear magnetic resonance imaging; single photon emission computer tomography; white matter, Brain; Cysteine; Female; Humans; Magnetic Resonance Imaging; Male; Multiple Sclerosis; Organotechnetium Compounds; Technetium Tc 99m Sestamibi; Tomography, Emission-Computed, Single-Photon; Treatment Outcome
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 22 Jul 2017 08:42
Last Modified: 22 Jul 2017 08:42
URI: http://eprints.goums.ac.ir/id/eprint/9296

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