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Association between left ventricular hypertrophy with retinopathy and renal dysfunction in patients with essential hypertension

Shirafkan, A. and Motahari, M. and Mojerlou, M. and Rezghi, Z. and Behnampour, N. and Gholamrezanezhad, A. (2009) Association between left ventricular hypertrophy with retinopathy and renal dysfunction in patients with essential hypertension. Singapore Medical Journal, 50 (12). pp. 1177-1183.

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Introduction: It has been suggested that hypertension (HTN) is associated with certain target organ damage (TOD) and related clinical conditions. On the other hand, left ventricular hypertrophy (LVH) has been considered as an independent risk factor of cardiovascular events and death. The aim of this study was to examine the relationship between HTN-induced LVH and TOD (retinopathy and renal failure). Methods: We assessed 102 hypertensive subjects (43 males and 59 females) with a mean age of 60.2 +/- 8.8 (range 35-81) years. LVH was defined as a left ventricular mass index (LVMI) of more than 51 and 47 g/(m to the power of 2.7), in men and women, respectively. The degree of retinopathy on ophthalmological examination was defined according to the Keith-Wagener classification. Serum creatinine, blood urea nitrogen and urine protein concentrations were also measured. Results: Hypertensive retinopathy was found in 94 (92.2 percent) cases (Grades I 55.9 percent; II 28.5 percent; III 3.9 percent; IV: 3.9 percent). The mean systolic and diastolic blood pressures and serum creatinine concentration showed significant correlation with the severity of LVH. There was no significant relationship between LVH severity and retinopathy or proteinuria. Conclusion: The tight control of systolic and diastolic blood pressures in the first step of essential hypertension can assist to postpone LVH. Furthermore, routine measurement of serum creatinine can predict the risk of cardiovascular complications in the hypertensive patient.

Item Type: Article
Additional Information: cited By 8
Uncontrolled Keywords: creatinine; nitrogen; protein; urea, adult; aged; article; blood pressure regulation; cardiovascular risk; creatinine blood level; diastolic blood pressure; disease association; disease classification; disease severity; essential hypertension; female; heart left ventricle hypertrophy; heart left ventricle mass; human; hypertension retinopathy; kidney dysfunction; major clinical study; male; ophthalmology; protein urine level; proteinuria; systolic blood pressure; urea nitrogen blood level, Adult; Aged; Aged, 80 and over; Blood Pressure Monitoring, Ambulatory; Cohort Studies; Creatinine; Electrocardiogram Pattern; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Kidney Failure, Chronic; Male; Middle Aged; Proteinuria; Retinal Diseases; Severity of Illness Index
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Depositing User: GOUMS
Date Deposited: 22 Jul 2017 08:39
Last Modified: 22 Jul 2017 08:39
URI: http://eprints.goums.ac.ir/id/eprint/9294

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