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Assessment of radioiodine clearance in patients with differentiated thyroid cancer

Tabei, F. and Asli, I.N. and Azizmohammadi, Z. and Javadi, H. and Assadi, M. (2012) Assessment of radioiodine clearance in patients with differentiated thyroid cancer. Radiation Protection Dosimetry, 152 (4). pp. 323-327.

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Abstract

Radioiodine (131I iodide) has long been a safe, effective and widely used treatment in the management of differentiated thyroid cancer (DTC). Concerns regarding stochastic radiogenic risks have led to regulatory criteria for the release from medical confinement of patients who receive such radionuclide therapy. Over a 6-y period, the external whole-body dose rates at 1 m from 562 DTC patients were measured with an ionisation chamber calibrated in microsieverts per hour out to 5-d post-administration. Patients were stratified into four administered activity groups: 3.7 GBq (36.8 ), 5.55 GBq (47.3 ), 7.4 GBq (12.8 ) and 9.25 GBq (3 ). Consistent with previously published data, the current study demonstrated that a bi-phasic model accurately described 131I-iodide kinetics up to at least 5-d post-administration in DTC patients, providing data that would be useful in formulating radiation safety guidelines for staff and other individuals coming into contact with such patients after treatment. © The Author 2012. Published by Oxford University Press. All rights reserved.

Item Type: Article
Additional Information: cited By 9
Uncontrolled Keywords: diagnostic agent; radioactive iodine, adult; antibody specificity; article; bioassay; body burden; female; human; male; metabolic clearance rate; metabolism; methodology; radiation dose; thyroid tumor; whole body counting, Adult; Biological Assay; Body Burden; Female; Humans; Iodine Radioisotopes; Male; Metabolic Clearance Rate; Organ Specificity; Radiation Dosage; Thyroid Neoplasms; Whole-Body Counting
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 22 Jul 2017 08:32
Last Modified: 25 Jul 2017 04:11
URI: http://eprints.goums.ac.ir/id/eprint/9293

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