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Long-term evaluation of a historical cohort of Iranian common variable immunodeficiency patients

Aghamohammadi, A. and Abolhassani, H. and Latif, A. and Tabassomi, F. and Shokuhfar, T. and Torabi Sagvand, B. and Shahinpour, S. and Mirminachi, B. and Parvaneh, N. and Movahedi, M. and Gharagozlou, M. and Sherkat, R. and Amin, R. and Aleyasin, S. and Faridhosseini, R. and Jabbari-Azad, F. and Cheraghi, T. and Eslamian, M.H. and Khalili, A. and Kalantari, N. and Shafiei, A. and Dabbaghzade, A. and Khayatzadeh, A. and Ebrahimi, M. and Razavinejad, D. and Bazregari, S. and Ebrahimi, M. and Ghaffari, J. and Bemanian, M.H. and Behniafard, N. and Kashef, S. and Mohammadzadeh, I. and Hammarström, L. and Rezaei, N. (2014) Long-term evaluation of a historical cohort of Iranian common variable immunodeficiency patients. Expert Review of Clinical Immunology, 10 (10). pp. 1405-1417.

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Abstract

Objectives: Common variable immune deficiency (CVID) is the most frequent form of symptomatic primary immunodeficiency disease, characterized by hypogammaglobulinemia, recurrent infections and increased predisposition to autoimmunity and malignancies. The aim of this study was to reconsider important points of previously performed studies on Iranian CVID patients diagnosed and followed from 1984 to 2013. Methods: Diagnosis was made using approved criteria including reductions of serum levels of immunoglobulins and exclusion of well-known single gene defects in individuals with an age >4 years and evidence of specific antibody deficiency. Results: Detailed information on demographic data, survival rates, clinical phenotypes, immunologic and genetic data and treatment of 173 patients are provided. The early onset presentation (74.5) and rate of consanguineous marriage (61.2) were considerably higher in our cohort. Our study revealed clinically related correlations regarding consanguinity, the population of naïve CD4+T cells and switched-memory B cells, cytokine levels and special genetic factors (including HLA and AID genes). Conclusion: Despite current efforts, more comprehensive studies are needed, especially for classification and investigation of the genetic background and prognostic factors for patients with CVID in order to better managment and followup of patinets. © 2014 Informa UK, Ltd.

Item Type: Article
Additional Information: cited By 10
Uncontrolled Keywords: CD4 antigen; cytokine; immunoglobulin, AID gene; autoimmunity; CD4+ T lymphocyte; cohort analysis; common variable immunodeficiency; consanguineous marriage; disease predisposition; evaluation study; gene; HLA gene; human; immunoglobulin blood level; immunoglobulin deficiency; Iran; memory cell; phenotype; prognosis; recurrent infection; Review; survival rate; adolescent; adult; child; common variable immunodeficiency; female; genetics; immunology; male; preschool child; young adult, Adolescent; Adult; Child; Child, Preschool; Cohort Studies; Common Variable Immunodeficiency; Female; Humans; Iran; Male; Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 08 Jul 2017 02:13
Last Modified: 08 Jul 2017 02:13
URI: http://eprints.goums.ac.ir/id/eprint/9273

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