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Cytotoxicity effect of Capparis spinosa L. On the HepG2 human hepatocellular carcinoma cell line

Sheikh, M. and Eshraghi, H.R. and Khoshnia, M. and Mazandarani, M. and Moradi, A. (2017) Cytotoxicity effect of Capparis spinosa L. On the HepG2 human hepatocellular carcinoma cell line. Indian Journal of Traditional Knowledge, 16 (1). pp. 73-77.

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Abstract

Hepatocellular carcinoma (HCC) is a complex condition associated with a poor prognosis. HCC is the third most common cause of cancer mortality which is continuously increasing. Capparis spinosa is used by traditional medical physicians in Iran to treat liver disorders and has been shown to prevent HCC. Treatment of HepG2 cells with Capparis spinosa ethanolic extract (CSE) inhibited cell proliferation in a dose dependent manner, and enhanced apoptosis of HepG2 cells by activation of caspase-8 and caspase-9 and down regulation of Bcl-2. Treatment of HepG2 cells with CSE also increased expression of the Cdk inhibitory protein (Cip1/p21). This study is a new design to investigate the in vitro effect of CSE on anti-HCC property. © 2017, National Institute of Science Communication and Information Resources (NISCAIR). All rights reserved.

Item Type: Article
Additional Information: cited By 1
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 18 Jun 2017 18:37
Last Modified: 18 Jun 2017 18:37
URI: http://eprints.goums.ac.ir/id/eprint/5117

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