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MicroRNA-196a as a Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma

Fendereski, M. and Zia, M.F. and Shafiee, M. and Safari, F. and Saneie, M.H. and Tavassoli, M. (2017) MicroRNA-196a as a Potential Diagnostic Biomarker for Esophageal Squamous Cell Carcinoma. Cancer Investigation, 35 (2). pp. 78-84.

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Abstract

We observed significant up-regulation of miR-196a in esophageal squamous cell carcinoma (ESCC) as compared with their adjacent normal tissue (p =.002). Receiver operating characteristics curve analysis confirmed the suitability of miR-196a as a potential tumor marker for diagnosis of ESCC. Furthermore, analysis of miR-196a levels in saliva samples determined an average of 27-fold up-regulations in ESCC patients compared with healthy group. Our results suggest that salivary miR-196a may be a suitable noninvasive biomarker for diagnosis of ESCC. In addition, molecular pathway enrichment analysis of microRNA (miR)-196a determined focal adhesion, spliceosome and p53 signaling pathways as the most relevant pathways with miR-196a targetome. © 2017 Taylor & Francis Group, LLC.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: microRNA; MIRN196 microRNA, human; paraffin; tumor marker, adult; aged; biosynthesis; Carcinoma, Squamous Cell; case control study; Esophageal Neoplasms; female; genetics; human; male; metabolism; middle aged; receiver operating characteristic; upregulation; very elderly, Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Case-Control Studies; Esophageal Neoplasms; Female; Humans; Male; MicroRNAs; Middle Aged; Paraffin Embedding; ROC Curve; Up-Regulation
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 18 Jun 2017 16:43
Last Modified: 18 Jun 2017 16:43
URI: http://eprints.goums.ac.ir/id/eprint/5097

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