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The efficacy of the ketogenic diet in infants and young children with refractory epilepsies using a formula-based powder

Ashrafi, M.R. and Hosseini, S.A. and Zamani, G.R. and Mohammadi, M. and Tavassoli, A. and Badv, R.S. and Heidari, M. and Karimi, P. and Malamiri, R.A. (2017) The efficacy of the ketogenic diet in infants and young children with refractory epilepsies using a formula-based powder. Acta neurologica Belgica, 117 (1). pp. 175-182.

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Abstract

To evaluate the efficacy, safety, and tolerability of a classic 4:1 ketogenic diet using a formula-based powder in infants and children with refractory seizures who are reluctant to eat homemade foods. We conducted an open label trial and administered a ketogenic diet using formula-based power (Ketocal®). Twenty-seven infants and children aged between 12 months and 5 years were enrolled who had refractory seizures and were reluctant to eat homemade foods. Of 27 children, 5 were lost to follow-up and 22 were remained at the end of the study. After 4 months, the median frequency of seizures per week was reduced >50 in 68.2 of patients, while 9/22 children (40.9) showed a 50-90 reduction in seizure frequency per week, and 6/22 children (27.3) showed more than 90 reduction in seizure frequency per week. Over the study course, 6/22 (27) children who continued to receive the diet developed constipation, one child developed gastroesophageal reflux, and one child developed hypercholesterolemia. None of these children discontinued the diet because of the complications. Thirteen children and their parents (59) reported that the diet was palatable and tolerable enough. The ketogenic diet using a formula-based powder (Ketocal®) is effective, safe, and tolerable in infants and children with refractory seizures who are reluctant to eat homemade foods according to the rules of the ketogenic diet.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: powder, adverse effects; artificial milk; clinical trial; diet therapy; epilepsy; female; human; infant; ketogenic diet; male; powder; preschool child; procedures, Child, Preschool; Epilepsy; Female; Humans; Infant; Infant Formula; Ketogenic Diet; Male; Powders
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 18 Jun 2017 16:03
Last Modified: 18 Jun 2017 16:03
URI: http://eprints.goums.ac.ir/id/eprint/5088

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