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Histologic and histomorphometric evaluation of bone regeneration using nanocrystalline hydroxyapatite and human freeze-dried bone graft: An experimental study in rabbit Histologische und histomorphometrische Evaluierung der Knochenregeneration mit nanokristallinem Hydroxylapatit und mit humanem gefriergetrocknetem Knochen: Eine experimentelle Studie am Kaninchenmodell

Sadeghi, R. and Najafi, M. and Semyari, H. and Mashhadiabbas, F. (2017) Histologic and histomorphometric evaluation of bone regeneration using nanocrystalline hydroxyapatite and human freeze-dried bone graft: An experimental study in rabbit Histologische und histomorphometrische Evaluierung der Knochenregeneration mit nanokristallinem Hydroxylapatit und mit humanem gefriergetrocknetem Knochen: Eine experimentelle Studie am Kaninchenmodell. Journal of Orofacial Orthopedics, 78 (2). pp. 144-152.

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Abstract

Purpose: Bone regeneration is an important concern in periodontal treatment and implant dentistry. Different biomaterials and surgical techniques have been used for this purpose. The aim of the present study was to compare the effect of nanocrystalline hydroxyapatite and human freeze-dried bone graft (FDBG) in regeneration of rabbit calvarium bony defects by histologic and histomorphometric evaluation. Methods: In this experimental study, three similar defects, measuring 8 mm in diameter, were created in the calvaria of 16 white New Zealand rabbits. Two defects were filled with FDBG and nanocrystalline hydroxyapatite silica gel, while the other one remained unfilled to be considered as control. All the defects were covered with collagen membranes. During the healing period, two animals perished; so 14 rabbits were divided into two groups: half of them were euthanized after 6 weeks of healing and the other half after 12 weeks. The specimens were subjected to histologic and histomorphometric examinations for assessment of the following variables: percentage of bone formation and residual graft material, inflammation scores, patterns of bone formation and type of newly formed bone. Results: The percentages of new bone formation after 6 weeks were 14.22 ± 7.85, 21.57 ± 6.91, and 20.54 ± 10.07 in FDBG, NanoBone, and control defects. These values were 27.54 ± 20.19, 23.86 ± 6.27, and 26.48 ± 14.18 in 12-week specimens, respectively. No significant differences were found in the amount of bone formation between the groups. With regard to inflammation, the control and NanoBone groups showed significantly less inflammation compared to FDBG at the 6-week healing phase (P = 0.04); this difference was not significant in the 12-week specimens. Conclusions: Based on the results of this experimental study, both NanoBone and FDBG exhibited a similar effect on bone formation. © 2017, Springer Medizin Verlag Berlin.

Item Type: Article
Additional Information: cited By 0
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 18 Jun 2017 16:02
Last Modified: 18 Jun 2017 16:02
URI: http://eprints.goums.ac.ir/id/eprint/5087

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