Golestan University of Medical Sciences Repository

Mutations in hepatitis-B X-gene region: Chronic hepatitis-B versus cirrhosis

Salarnia, F. and Besharat, S. and Zhand, S. and Javid, N. and Khodabakhshi, B. and Moradi, A. (2017) Mutations in hepatitis-B X-gene region: Chronic hepatitis-B versus cirrhosis. Journal of Clinical and Diagnostic Research, 11 (3). OC31-OC34.

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Abstract

Introduction: Specific mutations in Hepatitis-B Virus (HBV) genome would proceed the development of chronic hepatitis B to more serious consequences like cirrhosis and end-stage liver disease. Aim: This study was designed to detect deletion and insertion mutational patterns in the X-gene region in a population of chronic HBV and related cirrhosis patients. Materials and Methods: Sixty eight chronic HBV patients and 34 HBV-related cirrhotics were recruited from the eligible cases (N=50) referred to the academic hospitals of Gorgan city, Northeast of Iran, between Jan 2011 to Dec 2013. The HBx region was amplified by semi-nested PCR using serum samples and analyzed by sequencing. Results: Our findings showed deletions and insertions in the C-terminal of HBx of the cirrhotic group and 8 bp found in two chronic HBV cases (2.9). We detected 15 types of deletions in cirrhotic cases such as 1762-1768, 1763-1770, 1769-1773 and T1771/A1775. Conclusion: Considering the proposed role for some of these mutations in severe liver disease, further investigations are needed to clarify the importance of them in the early stages of hepatitis B infection. © 2017, Journal of Clinical and Diagnostic Research. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 18 Jun 2017 15:51
Last Modified: 18 Jun 2017 15:51
URI: http://eprints.goums.ac.ir/id/eprint/5082

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