Golestan University of Medical Sciences Repository

Frequent pUL27 Variations in HIV-Infected Patients

Mirarab, A. and Mohebbi, A. and Moradi, A. and Javid, N. and Vakili, M.A. and Tabarraei, A. (2017) Frequent pUL27 Variations in HIV-Infected Patients. Intervirology. pp. 262-266.

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Objective: Drug-resistant isolates of human cytomegalovirus (HCMV) have led to the development of new anti-HCMV drugs. Maribavir (MBV) is a novel inhibitor of the HCMV viral kinase. Resistance to MBV is mapped to gene UL27, a viral nuclear protein. In this study, we investigated UL27 polymorphisms in MBV-naive HIV-positive and HCMV congenitally infected clinical samples. Methods: DNA was extracted from 20 CMV-positive HIV (9/20) and congenitally infected (11/20) patients and used for UL27 polymerase chain reaction amplification. Sanger sequencing and multiple sequence alignment of products was performed. Results: K90 was the most prevalent polymorphism in both HIV-positive and congenitally infected patients. Polymorphisms Q54, D123, and R107 (10) were seen in more than one sample. There were significantly more polymorphisms in the HIV-positive samples (p = 0.038). Conclusion: HCMV pUL27 is highly variable in adult immunocompromised HIV-positive patients. © 2017 S. Karger AG, Basel

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Depositing User: GOUMS
Date Deposited: 18 Jun 2017 15:28
Last Modified: 18 Jun 2017 15:28
URI: http://eprints.goums.ac.ir/id/eprint/5073

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