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The acute effect of maximal exercise on plasma beta-endorphin levels in fibromyalgia patients

Bidari, A. and Ghavidel-Parsa, B. and Rajabi, S. and Sanaei, O. and Toutounchi, M. (2016) The acute effect of maximal exercise on plasma beta-endorphin levels in fibromyalgia patients. Korean Journal of Pain, 29 (4). pp. 249-254.

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Background: This study aimed to investigate the effect of strenuous exercise on β-endorphine (β-END) level in fibromyalgia (FM) patients compared to healthy subjects. Methods: We enrolled 30 FM patients and 15 healthy individuals. All study participants underwent a treadmill exercise test using modified Bruce protocol (M.Bruce). The goal of the test was achieving at least 70% of the predicted maximal heart rate (HRMax). The serum levels of β-END were measured before and after the exercise program. Measurements were done while heart rate was at least 70% of its predicted maximum. Results: The mean ± the standard deviation (SD) of exercise duration in the FM and control groups were 24.26 ± 5.29 and 29.06 ± 3.26 minutes, respectively, indicating a shorter time to achieve the goal heart rate in FM patients (P < 0.003). Most FM patients attained 70% HRMax at lower stages (stage 2 and 3) of M.Bruce compared to the control group (70% versus 6.6%, respectively; P < 0.0001). Compared to healthy subjects, FM patients had lower serum β-END levels both in baseline and post-exercise status (Mean ± SD: 122.07 ± 28.56 μg/ml and 246.55 ± 29.57 μg/ml in the control group versus 90.12 ± 20.91 μg/ml and 179.80 ± 28.57 μg/ml in FM patients, respectively; P < 0.001). Conclusions: We found that FM patients had lower levels of β-END in both basal and post-exercise status. Exercise increased serum the β-END level in both groups but the average increase in β-END in FM patients was significantly lower than in the control group. © The Korean Pain Society, 2016.

Item Type: Article
Additional Information: cited By 0
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Depositing User: GOUMS
Date Deposited: 13 Jun 2017 06:03
Last Modified: 13 Jun 2017 06:03
URI: http://eprints.goums.ac.ir/id/eprint/4938

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