Nickavar, A. and Safaeian, B. and Valavi, E. (2016) Evaluation and comparison of urinary cytokines for the diagnosis of acute pyelonephritis. Archives of Pediatric Infectious Diseases, 4 (4).
Full text not available from this repository.Abstract
Background: The accurate diagnosis and management of febrile urinary tract infection (UTI) is a clinical challenge in the absence of specific clinical and laboratory findings in infants and young children. Objectives: The aim of this study was to identify and compare the diagnostic and therapeutic implications of recently introduced cytokines for the diagnosis of acute pyelonephritis (APN). Methods: This multicenter prospective study was performed on 37 (female/male = 6.5:1) children with symptomatic culture-proven APNand 37 (female/male = 1.6/1) age-matched febrile children without UTIs as the control group. Urine samples were obtained before antibiotic treatment in both groups and 3 - 4 days after treatment in the UTI group, and evaluated for interleukin (IL)-1α, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, tumor necrosis factor- α (TNF α), monocyte chemoattractant protein-1 (MCP-1), and vascular endothelial growth factor (VEGF) using an ELISA immunoassay kit. Results: Mean urinary IL-1 α, IL-4, IL-6, and IL-8 concentrations significantly increased in the acute phase of APN compared to the control group, and decreased following antibiotic treatment. Conclusions: We recommend routine urinalysis and urine culture for the diagnosis of children with APN. Urinary IL-4 was a relatively good cytokine for the prediction and treatment-monitoring of children with acute febrile UTI. © 2016, Pediartric Infections Research Center.
| Item Type: | Article |
|---|---|
| Additional Information: | cited By 0 |
| Subjects: | مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus |
| Divisions: | UNSPECIFIED |
| Depositing User: | GOUMS |
| Date Deposited: | 12 Jun 2017 09:44 |
| Last Modified: | 12 Jun 2017 09:44 |
| URI: | http://eprints.goums.ac.ir/id/eprint/4897 |
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