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The association between prolonged jaundice and UGT1A1 gene polymorphism (G71R) in Gilbert’s syndrome

Alaee, E. and Bazrafshan, B. and Azaminejad, A.R. and Fouladinejad, M. and Shahbazi, M. (2016) The association between prolonged jaundice and UGT1A1 gene polymorphism (G71R) in Gilbert’s syndrome. Journal of Clinical and Diagnostic Research, 10 (11). GC05-GC08.

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Abstract

Introduction: Jaundice is a common condition during the neonatal period. Prolonged jaundice occurs in a large number of breastfed infants. Considering the impact of genetic factors on the incidence of jaundice present study was conducted. Aim: The aim of this study was to determine the association between prolonged jaundice and G71R polymorphism in Gilbert's syndrome. Materials and Methods: This case-control study was conducted at Taleghani Children’s Hospital of Gorgan, Iran. The study group consisted of 87 icteric patients (aged more than 2 weeks) with an indirect bilirubin level higher than 10mg/dL. The control group consisted of 81 newborns without jaundice. The two groups were matched in terms of age and gender. DNA extraction was performed by “phenol-chloroform” method. Polymerase Chain Reaction with Confronting Two-Pair Primers (PCR-CTPP) was applied to amplify G71R polymorphism. Results: Overall, 84% and 64% of subjects in the study and control groups were male, respectively. The distribution of Gilbert genotype was not significantly different between the two groups (p=0.772). There was a correlation between prolonged jaundice in males and UGT1A1 G71R polymorphism (p =0.03). In the study group, 5(5.7%) subjects were homozygous (for A/A), 73 (83.9%) were heterozygous (for A/G), and 9(10.3%) were normal (for G/G). In the control group, 3(3.7%) participants were homozygous (A/A), 68(84%) were heterozygous (A/G) and 10 (12.3%) were normal (G/G). Conclusion: There was no association between prolonged jaundice and G71R polymorphism, even though a relationship was revealed between male gender and the mentioned polymorphism. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.

Item Type: Article
Additional Information: cited By 1
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 12 Jun 2017 09:29
Last Modified: 12 Jun 2017 09:29
URI: http://eprints.goums.ac.ir/id/eprint/4885

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