Golestan University of Medical Sciences Repository

Mortality from respiratory diseases associated with opium use: A population-based cohort study

Rahmati, A. and Shakeri, R. and Khademi, H. and Poutschi, H. and Pourshams, A. and Etemadi, A. and Khoshnia, M. and Sohrabpour, A.A. and Aliasgari, A. and Jafari, E. and Islami, F. and Semnani, S. and Gharravi, A. and Abnet, C.C. and Pharoah, P.D.P. and Brennan, P. and Boffetta, P. and Dawsey, S.M. and Malekzadeh, R. and Kamangar, F. (2016) Mortality from respiratory diseases associated with opium use: A population-based cohort study. Thorax.

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Background Recent studies have suggested that opium use may increase mortality from cancer and cardiovascular diseases. However, no comprehensive study of opium use and mortality from respiratory diseases has been published. We aimed to study the association between opium use and mortality from respiratory disease using prospectively collected data. Methods We used data from the Golestan Cohort Study, a prospective cohort study in northeastern Iran, with detailed, validated data on opium use and several other exposures. A total of 50 045 adults were enrolled from 2004 to 2008, and followed annually until June 2015, with a follow-up success rate of 99%. We used Cox proportional hazard regression models to evaluate the association between opium use and outcomes of interest. Results During the follow-up period, 331 deaths from respiratory disease were reported (85 due to respiratory malignancies and 246 due to non-malignant aetiologies). Opium use was associated with an increased risk of death from any respiratory disease (adjusted HR 95% CI 3.13 (2.42 to 4.04)). The association was dose-dependent with a HR of 3.84 (2.61 to 5.67) for the highest quintile of cumulative opium use versus never use (Ptrend<0.001). The HRs (95% CI) for the associations between opium use and malignant and non-malignant causes of respiratory mortality were 1.96 (1.18 to 3.25) and 3.71 (2.76 to 4.96), respectively. Conclusions Long-term opium use is associated with increased mortality from both malignant and nonmalignant respiratory diseases. © 2016 BMJ Publishing Group Ltd & British Thoracic Society.

Item Type: Article
Additional Information: cited By 0; Article in Press
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Depositing User: GOUMS
Date Deposited: 12 Jun 2017 09:25
Last Modified: 12 Jun 2017 09:25
URI: http://eprints.goums.ac.ir/id/eprint/4881

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