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Effect of vitamin D3 supplement in glycemic control of pediatrics with type 1 diabetes mellitus and vitamin D deficiency

Mohammadian, S. and Fatahi, N. and Zaeri, H. and Vakili, M.A. (2015) Effect of vitamin D3 supplement in glycemic control of pediatrics with type 1 diabetes mellitus and vitamin D deficiency. Journal of Clinical and Diagnostic Research, 9 (3). SC05-SC07.

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Abstract

Background: Glycemic control prevents microvascular complications in patients with type I diabetes mellitus such as retinopathy, nephropathy and neuropathy that influences quality of life. Some studies show the immunomodulatory effect of vitamin D in synthesis and secretion of insulin. Aims: In this study we evaluate glycemic changes after vitamin D3 supplement in children with type I diabetes mellitus and vitamin D deficiency. Materials and Methods: In children with type I diabetes mellitus, level of vitamin D and HbA1C was measured. Patients with type I diabetes mellitus who had vitamin D deficiency (25OHD < 50 nmol/lit) treated with 300,000 units of vitamin D3. Calcium supplement (40mg/kg/day) divided in two doses in order to avoid hungry bone was also used. After three months, 25OHD and HbA1C were measured again. Differences, in mean ± SD HbA1C and 25OHD were evaluated before and after the study. Results: Mean ± SD HbA1C was 9.73±1.85 before the study which was diminished to 8.55±1.91 after vitamin D3 supplement treatment. This decline has a significant difference (p-value < 0.0001). Mean ± SD 25OHD was 17.33±8.97 nmol/lit before the study which is increased to 39.31±14.38 nmol/lit after treatment with vitamin D3 supplement. This increase also has a significant difference (p-value < 0.0001). Vitamin D3 supplement causes the improvement of HbA1C in all groups of glycemic control including HbA1C <7.8, 7.8-9.9, and >9.9. This supplement transfer patients toward better glycemic control for the entire group (p-value < 0.0001). Conclusion: Vitamin D3 supplement improves HbA1C in pediatrics with type I diabetes mellitus and vitamin D deficiency. © 2015, Journal of Clinical and Diagnostic Research. All Rights Reserved.

Item Type: Article
Additional Information: cited By 3
Uncontrolled Keywords: alkaline phosphatase; calcium; colecalciferol; creatinine; hemoglobin A1c; insulin aspart; insulin glargine; magnesium; parathyroid hormone; phosphorus; vitamin D, adolescent; Article; autoanalyzer; calcium urine level; chemoluminescence; child; controlled study; diabetic retinopathy; echography; enzyme linked immunosorbent assay; female; follow up; glucose blood level; glycemic control; human; hypercalciuria; infant; insulin dependent diabetes mellitus; kidney calcification; major clinical study; male; nephrolithiasis; pediatrics; single drug dose; vitamin D deficiency; vitamin supplementation
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: UNSPECIFIED
Depositing User: GOUMS
Date Deposited: 25 Dec 2016 05:39
Last Modified: 25 Dec 2016 05:39
URI: http://eprints.goums.ac.ir/id/eprint/4848

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