Golestan University of Medical Sciences Repository

Correlation between non-alcoholic fatty liver disease and carotid Intima-Media thickness in patient with type II diabetes

Hanafi, M.G. and Cina, M. and Zakerkish, M. and Rahim, F. and Saki-Malehi, A. and Nissi, Q. (2015) Correlation between non-alcoholic fatty liver disease and carotid Intima-Media thickness in patient with type II diabetes. International Journal of Osteoporosis and Metabolic Disorders, 8 (2). pp. 35-41.

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Non-Alcoholic Fatty Liver Disease (NAFLD) is a very prevalent condition determined by the infiltration of fat of liver cells. This study was conducted to evaluate the correlation between NAFLD and Carotid Intima-Media Thickness (CIMT) in patient with type II diabetes. This case-control study included three groups, including those with type II diabetes without NAFLD (n = 85), those with type II diabetes and NAFLD (n = 85) and non-diabetic individuals with only NAFLD (n = 85). The CIMT and the grading of the NAFLD were determined using an ultrasound B-mode. There was no significant difference between the case and control groups in term of overall mean of age (57±10 years vs. 56.9±8 years, respectively). Considering the two factors (diabetes and NAFLD) effect, with adjustment for age and gender as a confounding effect of diabetes (p = 0.01) and NAFLD (p = 0.022) on CIMT was significant. The mean right CIMT, left CIMT and overall CIMT in three different study groups of diabetic patients, according to various NAFLD grading showed no significant difference. Our findings showed a considerable association between NAFLD and increased CIMT, in which this association is not affected by the severity of fatty liver. So, immediate ultrasound screening and treatment for the patients with NAFLD are recommended to prevent CVD complications such as atherosclerosis considering early stages of fatty liver disease. © 2015 Asian Network for Scientific Information.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: adult; arterial wall thickness; Article; case control study; controlled study; correlational study; disease association; disease severity; female; human; major clinical study; male; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; sex difference
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 09:15
Last Modified: 10 Sep 2016 09:15
URI: http://eprints.goums.ac.ir/id/eprint/4825

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