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99mtc-igg-lung scintigraphy in the assessment of pulmonary involvement in interstitial lung disease and its comparison with pulmonary function tests and high-resolution computed tomography: A preliminary study

Bahtouee, M. and Saberifard, J. and Javadi, H. and Nabipour, I. and Malakizadeh, H. and Monavvarsadegh, G. and Pak, H.I. and Sadeghi, A. and Assadi, M. (2015) 99mtc-igg-lung scintigraphy in the assessment of pulmonary involvement in interstitial lung disease and its comparison with pulmonary function tests and high-resolution computed tomography: A preliminary study. Iranian Journal of Radiology, 12 (4).

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Abstract

Background: The discrimination of inactive inflammatory processes from the active form of the disease is of great importance in the management of interstitial lung disease (ILD). Objectives: The aim of this study was to determine the efficacy of 99mTc-IgG scan for the detection of severity of disease compared to high- resolution computed tomography (HRCT) and pulmonary function test (PFT). Patients and Methods: Eight known cases of ILD including four cases of Mustard gas (MG) intoxication and four patients with ILD of unknown cause were included in this study. A population of six patients without lung disease was considered as the control group. The patients underwent PFT and high-resolution computed tomography scan, followed by 99mTc-IgG scan. They were followed up for one year. 99mTc-IgG scan assessment of IgG uptake was accomplished both qualitatively (subjectively) and semiquantitatively. Results: All eight ILD patients demonstrated a strong increase in 99mTc-IgG uptake in the lungs, compared to the control patients. The 99mTc-IgG scan scores were higher in the patient group (0.64[95% confidence interval (CI)=0.61-0.69])) than the control group (0.35 (0.35[95% CI=0.28-0.40]), (P<0.05)). In patients, a statistically significant positive correlation was detected between 99mTc-IgG scan and HRCT scores (Spearman’s correlation coefficient = 0.92, P < 0.008). The 99mTc-Human Immunoglobulin (HIG) scores were not significantly correlated with PFT findings (including FVC, FEV1, FEV1/FVC), O2 saturation and age (P values > 0.05). There were no significant correlations between 99mTc-IgG score and HRCT patterns including ground glass opacity, reticular fibrosis and honeycombing (P value > 0.05). Conclusion: The present results confirmed that 99mTc-IgG scan could be applied to detect the severity of pulmonary involvement, which was well correlated with HRCT findings. This data also showed that the 99mTc-IgG scan might be used as a complement to HRCT in the functional evaluation of the clinical status in ILD; however, further studies are recommended. © 2015, Tehran University of Medical Sciences and Iranian Society of Radiology.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: immunoglobulin G; technetium 99m, adult; age distribution; aged; Article; clinical article; clinical effectiveness; controlled study; diagnostic test accuracy study; disease severity; female; forced expiratory volume; forced vital capacity; gas poisoning; high resolution computer tomography; human; intermethod comparison; interstitial lung disease; lung function test; lung scintiscanning; male; oxygen saturation; radiological parameters
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 08:54
Last Modified: 14 Jan 2017 09:14
URI: http://eprints.goums.ac.ir/id/eprint/4812

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