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Relationship of cortisol, norepinephrine, and epinephrine levels with war-induced posttraumatic stress disorder in fathers and their offspring

Yahyavi, S.T. and Zarghami, M. and Naghshvar, F. and Danesh, A. (2015) Relationship of cortisol, norepinephrine, and epinephrine levels with war-induced posttraumatic stress disorder in fathers and their offspring. Revista Brasileira de Psiquiatria, 37 (2). pp. 93-98.

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Abstract

Objective: To compare afternoon serum/plasma levels of hormones in four groups: (A) veterans with posttraumatic stress disorder (PTSD), (B) offspring of PTSD veterans, (C) veterans without PTSD, and (D) offspring of non-PTSD veterans. Methods: Evaluation consisted of a semi-structured interview for axis I and II diagnoses, followed by measurement of afternoon serum cortisol and plasma epinephrine and norepinephrine by ELISA (Diametra) and LND (LDN Labor Diagnostika Nord GmbH & Co. KG) respectively. Data were analyzed using descriptive statistics and the Student t, Kolmogorov-Smirnov, and nonparametric Mann-Whitney tests. Results: One hundred and sixty-eight volunteers were investigated across the four groups. The groups were similar in terms of demographic characteristics, war experience and traumatization, and psychiatric and medical conditions other than PTSD (group A was similar to group C and group B was similar to group D). Between-groups comparisons did not yield statistically significant differences. Post-hoc analyses revealed significant differences in afternoon cortisol level between the offspring of veterans with current/past history of PTSD and the offspring of veterans without a history of PTSD. Conclusion: We only found decreased cortisol levels in offspring of veterans after rearranging the groups to reflect previous history of PTSD. Further studies are required to investigate the relationship between cortisol levels and the transgenerational effects of trauma and parental PTSD. © 2015, Associacao Brasileira de Psiquiatria. All rights reserved.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: adrenalin; hydrocortisone; noradrenalin; biological marker; hydrocortisone; noradrenalin, adult; Article; battle injury; blood analysis; child; clinical article; controlled study; disease association; disease severity; DSM-IV-TR; enzyme linked immunosorbent assay; female; genetic analysis; human; male; posttraumatic stress disorder; Structured Clinical Interview for DSM Disorders; blood; father; father child relation; middle aged; posttraumatic stress disorder; psychology; socioeconomics; veteran; war, Adult; Biomarkers; Father-Child Relations; Fathers; Female; Humans; Hydrocortisone; Iraq War, 2003-2011; Male; Middle Aged; Norepinephrine; Socioeconomic Factors; Stress Disorders, Post-Traumatic; Veterans
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 08:36
Last Modified: 14 Jan 2017 06:13
URI: http://eprints.goums.ac.ir/id/eprint/4804

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