Golestan University of Medical Sciences Repository

Cytomegalovirus infection and atherosclerosis in candidate of coronary artery bypass graft

Heybar, H. and Alavi, S.M. and Nejad, M.F. and Latifi, M. (2015) Cytomegalovirus infection and atherosclerosis in candidate of coronary artery bypass graft. Jundishapur Journal of Microbiology, 8 (3).

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Abstract

Background: Although there is enough evidence that infectious agents such as Chlamydia pneumonia and Helicobacter pylori may play a pathogenic role in atherosclerosis, this role for cytomegalovirus (CMV) is yet controversial. Objectives: The aim of the present study was to detect CMV-DNA in atherosclerotic plaques in patients who underwent coronary artery bypass graft (CABG). Patients and Methods: In this case-control study, candidates for CABG (cases) and patients with valvular or congenital malformation but without atherosclerotic plaques (controls) were studied from 2012 to 2013 at Golestan hospital, Ahvaz, IR Iran. Demographic and laboratory data were collected. Atherosclerotic and histological samples were obtained from visible plaques and from aorta by the surgeon. All the samples were examined for the presence of CMV-DNA by polymerase chain reaction (PCR) method using a commercial kit (SinaClon, Tehran, IR Iran). Results: The mean ages in case and control groups were 60.8 ± 6.8 and 57.5 ± 11.5 years, respectively, with no significant difference (P = 0.09). Thirty patients (54.5%) in case and 32 (58.2%) in control groups were male with no significant difference (P = 0.7). CMV-DNA was present in 8 (14.5%) of the cases and 2 (4%) of the controls. CMV-DNA was associated with higher risk of atherosclerosis (OR: 7.7, 95% CI = 1.1-51.4, P = 0.03). Of the total normal aortic samples (55 in cases and 55 in controls), there was no individual with simultaneous positive CMV-DNA among aortic atherosclerotic and normal tissue samples. Conclusions: The presence of CMV-DNA in aortic plaques is associated with increased risk of atherosclerosis. CMV infection may be considered as an independent risk factor for this event. © 2015, Ahvaz Jundishapur University of Medical Sciences.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: virus DNA, adult; Article; atherogenesis; atherosclerotic plaque; case control study; cohort analysis; congenital heart malformation; controlled study; coronary artery atherosclerosis; coronary artery bypass graft; cytomegalovirus infection; disease association; disease predisposition; female; histopathology; human; human tissue; Iran; major clinical study; male; polymerase chain reaction; polymerase chain reaction system; risk factor; valvular heart disease, Chlamydia; Cytomegalovirus; Helicobacter pylori
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 08:35
Last Modified: 10 Sep 2016 08:35
URI: http://eprints.goums.ac.ir/id/eprint/4803

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