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Acute effects of simvastatin to terminate fast reentrant tachycardia through increasing wavelength of atrioventricular nodal reentrant tachycardia circuit

Khori, V. and Alizadeh, A.M. and Moheimani, H.R. and Zahedi, M. and Aminolsharieh Najafi, S. and Shakiba, D. and Nayebpour, M. (2015) Acute effects of simvastatin to terminate fast reentrant tachycardia through increasing wavelength of atrioventricular nodal reentrant tachycardia circuit. Fundamental and Clinical Pharmacology, 29 (1). pp. 41-53.

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Abstract

Simvastatin (SV) leads to reduction of ventricular rhythm during atrial fibrillation on rabbit atrioventricular (AV) nodes. The aim of our study was (i) to determine the frequency-dependent effects of SV in a functional model, and (ii) to assess the effects of SV to suppress experimental AV nodal reentrant tachycardia (AVNRT). Selective stimulation protocols were used with two different pacing protocols, His to atrial, and atrial to atrial (AA). An experimental AVNRT model with various cycle lengths was created in three groups of perfused rabbit AV nodal preparations (n = 24) including: SV 3 μm, SV 7 μm, and verapamil 0.1 μm. SV increased nodal conduction time and refractoriness by AA pacing. Different simulated models of slow/fast and fast/slow reentry were induced. SV caused inhibitory effects on the slow anterograde conduction (origin of refractoriness) more than on the fast anterograde conduction time, leading to an increase of tachycardia cycle length, tachycardia wavelength and termination of slow/fast reentrant tachyarrhythmia. Verapamil significantly suppressed the basic and frequency-dependent intrinsic nodal properties. In addition, SV decreased the incidence of gap and echo beats. The present study showed that SV in a concentration and rate-dependent manner increased the AV effective refractory period and reentrant tachycardia wavelength that lead to slowing or termination of experimental fast AVNRT. The direction-dependent inhibitory effect of SV on the anterograde and retrograde dual pathways explains its specific antireentrant actions. © 2014 Société Française de Pharmacologie et de Thérapeutique.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: simvastatin; verapamil; simvastatin; verapamil, animal experiment; animal model; animal tissue; Article; atrioventricular nodal reentry tachycardia; controlled study; drug efficacy; experimental rabbit; heart atrium; heart atrium pacing; heart muscle refractory period; His bundle; male; nonhuman; priority journal; animal; atrial fibrillation; congenital malformation; drug effects; electrocardiography; heart arrhythmia; heart atrioventricular node; heart muscle conduction system; heart rate; procedures; rabbit; tachycardia; Tachycardia, Atrioventricular Nodal Reentry, Animals; Arrhythmias, Cardiac; Atrial Fibrillation; Atrioventricular Node; Electrocardiography; Heart Conduction System; Heart Rate; Male; Rabbits; Simvastatin; Tachycardia; Tachycardia, Atrioventricular Nodal Reentry; Verapamil
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 08:30
Last Modified: 17 Jan 2017 08:22
URI: http://eprints.goums.ac.ir/id/eprint/4801

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