Golestan University of Medical Sciences Repository

Assessment of correlation between androgen receptor cag repeat length and infertility in infertile men living in khuzestan, iran

Khatami, S.R. and Galehdari, H. and Rasekh, A. and Mombeini, H. and Konar, E. (2015) Assessment of correlation between androgen receptor cag repeat length and infertility in infertile men living in khuzestan, iran. International Journal of Fertility and Sterility, 9 (2). pp. 189-196.

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Abstract

Background: The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat that encodes a polyglutamine tract in its N-terminal transactivation domain (NTAD). We aimed to find a correlation between the length of this polymorphic tract and azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran. Materials and Methods: In this case-control study during two years till 2010, we searched for microdeletions in the Y chromosome in 84 infertile male patients with normal karyotype who lived in Khuzestan Province, Southwest of Iran. All cases (n=12) of azoospermia or oligozoospermia resulting from Y chromosome microdeletions were excluded from our study. The number of CAG repeats in exon 1 of the AR gene was determined in 72 patients with azoospermia or oligozoospermia and in 72 fertile controls, using the polymerase chain reaction (PCR) and polyacrylamide gel electrophoresis. Results: Microdeletions were detected in 14.3% (n=12) patients suffering severe oligozoospermia. The mean CAG repeat length was 18.99 ± 0.35 (range, 11-26) and 19.96 ± 0.54 (range, 12-25) in infertile males and controls, respectively. Also in the infertile group, the most common allele was 19 (26.38%), while in controls, it was 25 (22.22%). Conclusion: Y chromosome microdeletions could be one of the main reasons of male infertility living in Khuzestan Province, while there was no correlation between CAG length in AR gene with azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran. © 2015 Royan Institute (ACECR). All Rights Reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: androgen receptor; DNA polymerase; genomic DNA, adult; allele; Article; CAG repeat; case control study; controlled study; gene frequency; human; Iran; major clinical study; male; male infertility; oligospermia; patient assessment; polyacrylamide gel electrophoresis; polymerase chain reaction; semen analysis; world health organization; Y chromosome
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 08:08
Last Modified: 10 Sep 2016 08:08
URI: http://eprints.goums.ac.ir/id/eprint/4786

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