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Effect of filgrastim (Recombinant human granulocyte colony stimulating factor) on spatial memory in aged rats

Sepehri, H. and Mehrazin, E. (2015) Effect of filgrastim (Recombinant human granulocyte colony stimulating factor) on spatial memory in aged rats. National Journal of Physiology, Pharmacy and Pharmacology, 5 (5). pp. 421-425.

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Background: Apart from functioning as a multimodal hematopoietic growth factor, granulocyte colony-stimulating factor (G-CSF) causes intense consequences on the brain. It has been viewed that G-CSF boosts the improvement from the neurologic deficits in rodent models of central nervous system diseases. Aims and Objective: To evaluate the efficacy of G-CSF as an intervention for improving cognitive deficits commonly associated with aging. Materials and Methods: In this study, male Wistar rats aged 21 months were treated for 2 weeks with G-CSF intraperitoneally at doses of 10, 50, and 70 mg/kg/day. The learning process was assessed by the reference memory task in the Morris water maze, by comparing the G-CSF–treated group with the control animals. All the rats received Morris water maze training (four trials/day for 5 days) in order to assess the hippocampal-dependent spatial learning and received a 60-s probe trial test of spatial memory retention 24 h after the twentieth trial. Result: Over 5 days of training, G-CSF (10, 50, and70 mg/kg/day) significantly reduced the latency and path length to finding the escape platform (P < 0.01). In probe trials (without platform), on the last day of training, the G-CSF–treated group spent significantly longer time in the platform quadrant when compared with the control animals (P < 0.01). Among the treated groups, the 50-mg/kg dosage of G-CSF induced the best rehearsals memory. Conclusion: The findings observed in this study support G-CSF as a promising therapeutic aid for cognitive enhancement in the aging phenomenon. © 2015 Hamid Sepehri.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: filgrastim, aged; aging; Article; cognitive defect; controlled study; latent period; learning; male; memory test; Morris water maze test; nonhuman; rat; spatial memory; swimming; training
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 07:13
Last Modified: 25 Dec 2016 05:11
URI: http://eprints.goums.ac.ir/id/eprint/4767

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