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Genetic polymorphism of cytochrome p450 (2C9) enzyme in Iranian Baluch ethnic group

Tabari, M.G. and Naseri, F. and Ataby, M.A. and Marjani, A. (2015) Genetic polymorphism of cytochrome p450 (2C9) enzyme in Iranian Baluch ethnic group. Open Biochemistry Journal, 9. pp. 37-41.

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Abstract

The aim of the present study is to assess and compare the frequencies of the cytochrome P450 CYP2C9 variations in the Baluch ethnic group (n=110) with other ethnic groups. The allele frequencies of CYP2C9*1, CYP2C9*2 and CYP2C9*3 were 80.90%, 11.82% and 7.27%, respectively. 70.90%, 11.82%, 8.18%, 4.55%, 2.73% and 1.82% of subjects were with CYP2C9*1/*1, CYP2C9*1/*2, CYP2C9*1/*3, CYP2C9*2/*2, CYP2C9*2/*3 and CYP2C9*3/*3 genotypes, respectively. Different mutants may effect on prediction of drug dose requirements in different ethnic groups. Thus, CYP2C9 variants to be determined for findings high risk groups use optimal dosage of drugs metabolized by this polymorphic enzyme. © Tabari et al.; Licensee Bentham Open.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: cytochrome P450 2C9; cytochrome P450 2C9 1/1; cytochrome P450 2C9 1/2; cytochrome P450 2C9 1/3; cytochrome P450 2C9 2/2; cytochrome P450 2C9 2/3; cytochrome P450 2C9 3/3; unclassified drug, adolescent; adult; allele; Article; DNA extraction; ethnicity; gene frequency; genetic polymorphism; genetic variability; human; normal human; polymerase chain reaction; population genetics; priority journal; restriction fragment length polymorphism
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 06:42
Last Modified: 15 Jan 2017 18:34
URI: http://eprints.goums.ac.ir/id/eprint/4748

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