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Impact of creatinine clearance on helicobacter pylori eradication rate in patients with peptic ulcer disease

Alimadadi, M. and Seyyedmajidi, M. and Amirkhanlou, S. and Hafezi, A.A. and Homapour, S. and Vafaeimanesh, J. and Vakili, M.A. (2015) Impact of creatinine clearance on helicobacter pylori eradication rate in patients with peptic ulcer disease. Iranian Journal of Kidney Diseases, 9 (6). pp. 427-432.

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Abstract

Introduction. Gastrointestinal complaints are common in patients with kidney failure. The aim of this study was to investigate the effect of creatinine clearance on Helicobacter pylori (HP) eradication rate in patients with peptic ulcer disease. Materials and Methods. In this clinical trial, 132 patients with a range of kidney function (normal to end-stage renal disease) and peptic ulcer disease with HP infection were enrolled and divided into 5 groups by their creatinine clearance. For all patients, a 14-day standard regimen of triple therapy for peptic ulcer was started with omeprazole, 20 mg; clarithromycin, 500 mg; and amoxicillin, 1 g; twice per day. After 6 weeks, HP eradication rate were evaluated and compared between the groups with urea breath test. Results. The mean age of the participants was 44.84 ± 12.20 years and 68 (51.5%) were women. The five groups were not significantly different in terms of age, sex distribution, or body mass index. The results of urea breath test at 6 weeks were positive in 23 patients (17.4%). There was no significant difference in HP eradication rate (negative urea breath test) between the five groups. Conclusions. This study showed no association between the success rate of eradication of HP infection and kidney function. © 2015, Iranian Society of Nephrology. All rights reserved.

Item Type: Article
Additional Information: cited By 1
Uncontrolled Keywords: amoxicillin plus clarithromycin plus omeprazole; amoxicillin; antiinfective agent; clarithromycin; creatinine; omeprazole; proton pump inhibitor, adult; Article; bacterial clearance; clinical trial; controlled study; creatinine clearance; esophagogastroduodenoscopy; female; gastroscopy; Helicobacter infection; human; kidney failure; kidney function; male; peptic ulcer; urea breath test; breath analysis; chronic kidney failure; combination drug therapy; complication; controlled clinical trial; Helicobacter Infections; Helicobacter pylori; metabolism; microbiology; middle aged; pathophysiology; peptic ulcer; treatment outcome, Adult; Amoxicillin; Anti-Bacterial Agents; Breath Tests; Clarithromycin; Creatinine; Drug Therapy, Combination; Female; Helicobacter Infections; Helicobacter pylori; Humans; Kidney Failure, Chronic; Male; Middle Aged; Omeprazole; Peptic Ulcer; Proton Pump Inhibitors; Treatment Outcome
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 06:00
Last Modified: 09 Jan 2017 08:03
URI: http://eprints.goums.ac.ir/id/eprint/4729

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