Golestan University of Medical Sciences Repository

Interleukin-1 alpha variation is associated with the risk of developing preeclampsia

Ghasemi, M. and Kashani, E. and Fayyaz, A. and Attar, M. and Shahbazi, M. (2015) Interleukin-1 alpha variation is associated with the risk of developing preeclampsia. European Journal of Obstetrics Gynecology and Reproductive Biology, 193. pp. 75-78.

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Abstract

Objective Preeclampsia is a syndrome that affects 5 of all pregnancies, producing substantial maternal and prenatal morbidity and mortality. Several studies have reported that cytokine genes are associated with the persistence of preeclampsia or the severity of the disease. The aim of this study is to investigate the relationships between the polymorphisms of interleukin-1 alpha-889 (IL-1A) gene and preeclampsia. Method Genomic DNA was extracted from the peripheral blood of 305 patients with preeclampsia and 325 normal controls from Sayyad Shirazi Hospital of Golestan University. Then subjected to SSP-PCR amplification. STATA software and the chi square test were used for statistic calculations. Results The frequencies of IL-1A -889 genotypes C/C, T/T and C/T in preeclampsia cases were 34.8, 8.2, 57 and in controls were 20.9, 7.6 and 71.3 respectively. There was a significant 1.5 fold excess frequency in genotype C/C in cases (CI = 1.44-3.07, OR = 2.1, P = 0.0001). There was a significant difference in the frequencies of alleles or genotypes in IL-1A promoter regions between patients with preeclampsia and the control group. Turkomans showed the highest frequency of the C allele and Sistanies had the lowest frequency of the C allele in preeclampsia compared to control groups (CI = 1.5-3.9, OR = 2.48, P = 0.0001). Conclusion Our findings suggest that the IL-1A-899C/C genotype and C allele are associated with susceptibility to preeclampsia. © 2015 Elsevier Ireland Ltd. All rights reserved.

Item Type: Article
Additional Information: cited By 0
Uncontrolled Keywords: genomic DNA; interleukin 1alpha; interleukin 1alpha, adult; allele; Article; computer program; controlled study; female; gene frequency; genetic association; genetic polymorphism; genetic susceptibility; genetic variability; genotype; human; major clinical study; preeclampsia; priority journal; promoter region; Turkmen (people); adolescent; case control study; ethnology; genetics; Iran; preeclampsia; pregnancy; single nucleotide polymorphism; young adult, Adolescent; Adult; Case-Control Studies; Female; Gene Frequency; Genotype; Humans; Interleukin-1alpha; Iran; Polymorphism, Single Nucleotide; Pre-Eclampsia; Pregnancy; Promoter Regions, Genetic; Young Adult
Subjects: مقالات نمایه شده محققین دانشگاه در سایت ,Web of Science ,Scopus
Divisions: معاونت تحقیقات و فناوری
Depositing User: GOUMS
Date Deposited: 10 Sep 2016 05:49
Last Modified: 09 Jan 2017 09:25
URI: http://eprints.goums.ac.ir/id/eprint/4722

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